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We examined the effects of decursin extracted from <jats:italic>Angelica gigas<\/jats:italic> Nakai on antioxidant activity <jats:italic>in vitro<\/jats:italic> and in a cryptorchidism\u2010induced infertility rat model. TM3 Leydig cell viability was measured based on oxidative stress according to treatment. Either distilled water or AG 400\u2009mg\/kg of <jats:italic>A. gigas<\/jats:italic> extract was administered orally for 4 weeks after unilateral cryptorchidism was induced. After 1, 2, and 4 weeks, six rats from the control group and six rats from treatment group were sacrificed. Testicular weight, semen quality, antioxidant activities, nuclear factor erythroid 2\u2010related factor 2 (Nrf2) protein, and mRNA expression of Nrf2\u2010regulated genes were analyzed. Treatment with <jats:italic>A. gigas<\/jats:italic> extract (1) protected TM3 cells against oxidative stress in a dose\u2010dependent manner, (2) improved the mean weight of the cryptorchid testis, (3) maintained sperm counts, motility, and spermatogenic cell density, (4) decreased levels of 8\u2010hydroxy\u20102\u2010deoxyguanosine (8\u2010OHdG) and increased levels of superoxide dismutase (SOD), (5) significantly increased Nrf2 and heme oxygenase\u20101 (HO\u20101), and (6) significantly decreased apoptosis. This study suggests that decursin extracted from <jats:italic>A. gigas<\/jats:italic> is a supplemental agent that can reduce oxidative stress by Nrf2\u2010mediated upregulation of HO\u20101 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism\u2010induced infertility.<\/jats:p>","DOI":"10.1155\/2016\/5901098","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T21:01:19Z","timestamp":1455656479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Protective Effect of Decursin Extracted from <i>Angelica gigas<\/i> in Male Infertility via Nrf2\/HO\u20101 Signaling Pathway"],"prefix":"10.1155","volume":"2016","author":[{"given":"Woong Jin","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. 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