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Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO<jats:sub>2<\/jats:sub>laser (10\u2009W, 606\u2009J\/cm<jats:sup>2<\/jats:sup>) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10\u2009W CO<jats:sub>2<\/jats:sub>laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and<jats:italic>\u03b2<\/jats:italic>-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated<jats:italic>\u03b2<\/jats:italic>-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage.<\/jats:p>","DOI":"10.1155\/2016\/5982397","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:33:05Z","timestamp":1481761985000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of the Damage Mechanism Related to CO<sub>2<\/sub>Laser Cochleostomy on Guinea Pig Cochlea"],"prefix":"10.1155","volume":"2016","author":[{"given":"Xiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otology & Skull Base Surgery, EYE & ENT Hospital of Fudan University, Shanghai 200031, China"},{"name":"Shanghai Clinical Medical Center of Hearing Medicine, Shanghai 200031, China"},{"name":"Key Laboratory of Hearing Medicine, Ministry of Health, Shanghai 200031, 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