{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:38:51Z","timestamp":1761896331081},"reference-count":23,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma (MM). A few reports have linked bortezomib exposure with the development of thrombotic microangiopathy (TMA). We describe a case of biopsy-proven renal thrombotic microangiopathy associated with the use of bortezomib in a 51-year-old man with IgG lambda MM. To our knowledge, this is the first biopsy-proven case. In addition, reexposure to bortezomib 18 months later was associated with recurrence of TMA. This supports a possible causal role of bortezomib. The exact mechanisms remain to be elucidated.<\/jats:p>","DOI":"10.1155\/2016\/6020691","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T21:01:34Z","timestamp":1463432494000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Renal Thrombotic Microangiopathy Associated with the Use of Bortezomib in a Patient with Multiple Myeloma"],"prefix":"10.1155","volume":"2016","author":[{"given":"Jan","family":"Van Keer","sequence":"first","affiliation":[{"name":"Cardiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Delforge","sequence":"additional","affiliation":[{"name":"Hematology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan","family":"Dierickx","sequence":"additional","affiliation":[{"name":"Hematology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathelijne","family":"Peerlinck","sequence":"additional","affiliation":[{"name":"Vascular Medicine and Hemostasis, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Lerut","sequence":"additional","affiliation":[{"name":"Pathology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Sprangers","sequence":"additional","affiliation":[{"name":"Nephrology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra020528"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0140-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02458.x"},{"issue":"2, article e13","key":"4","volume":"4","year":"2012","journal-title":"Hematology Reports"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-006461"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.977887"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05188.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa030288"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1213206"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21371"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-156"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv059"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)02799-9"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-12-200112180-00008"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G067"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1517\/14740330902942299"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1312353"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.11.039"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0707330"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1195"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01544.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp315"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e3182603598"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2016\/6020691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2016\/6020691.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2016\/6020691.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T14:59:59Z","timestamp":1469545199000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2016\/6020691\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":23,"alternative-id":["6020691","6020691"],"URL":"https:\/\/doi.org\/10.1155\/2016\/6020691","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}