{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:56:13Z","timestamp":1763535373097},"reference-count":23,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Beh\u00e7et\u2019s disease patients with those of healthy controls.<jats:italic>Methods<\/jats:italic>. This case-control study compared a group of 30 patients with Beh\u00e7et\u2019s disease with an age- and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented.<jats:italic>Results<\/jats:italic>. The nuclear and cytoplasmic areas of the BD patients\u2019 cells were significantly smaller than those of the healthy controls\u2019 cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae.<jats:italic>Conclusion<\/jats:italic>. Beh\u00e7et\u2019s disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques.<\/jats:p>","DOI":"10.1155\/2016\/6035801","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T18:40:45Z","timestamp":1458585645000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Cytomorphometric Characteristics of Buccal Mucosal Cells in Beh\u00e7et\u2019s Disease Patients"],"prefix":"10.1155","volume":"2016","author":[{"given":"Erol","family":"Aktunc","sequence":"first","affiliation":[{"name":"School of Medicine, Department of Family Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra Safi","family":"Oz","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Medical Biology, Bulent Ecevit University, 67600 Zonguldak, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Bektas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taksim Education and Research Hospital, 34433 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cevdet","family":"Altinyazar","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Dermatology, Sel\u00e7uk University, 42075 Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafet","family":"Koca","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Dermatology, Bulent Ecevit University, 67600 Zonguldak, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Bostan","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Dermatology, Bulent Ecevit University, 67600 Zonguldak, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12107"},{"issue":"4","key":"2","first-page":"S53","volume":"22","year":"2004","journal-title":"Clinical and Experimental Rheumatology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1076\/opep.9.5.325.10338"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01893.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2008.0484"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00162.x"},{"issue":"11","key":"7","first-page":"E693","volume":"13","year":"2008","journal-title":"Medicina Oral, Patologia Oral y Cirugia Bucal"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.50.335"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1159\/000320881"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2330\/joralbiosci.53.158"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.145642"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00779.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.667852"},{"issue":"6","key":"14","first-page":"311","volume":"32","year":"2010","journal-title":"Analytical and Quantitative Cytology and Histology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/247853"},{"issue":"3","key":"16","first-page":"176","volume":"10","year":"1988","journal-title":"Analytical and Quantitative Cytology and Histology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.112652"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.09.011"},{"issue":"12","key":"19","first-page":"725","volume":"16","year":"2013","journal-title":"Archives of Iranian Medicine"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1309\/GCTH-0060-55K8-XCTT"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1179\/1351000213Y.0000000072"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0513-x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06543.x"}],"container-title":["Analytical Cellular Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2016\/6035801.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2016\/6035801.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/acp\/2016\/6035801.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T17:52:21Z","timestamp":1471542741000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/acp\/2016\/6035801\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":23,"alternative-id":["6035801","6035801"],"URL":"https:\/\/doi.org\/10.1155\/2016\/6035801","relation":{},"ISSN":["2210-7177","2210-7185"],"issn-type":[{"value":"2210-7177","type":"print"},{"value":"2210-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}