{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T01:32:55Z","timestamp":1648690375565},"reference-count":11,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>This is a case of a 23-year-old African American male with a history of paranoid schizophrenia that developed neutropenia on a clozapine-topiramate therapy. Clozapine had well addressed the patient\u2019s psychotic symptoms, while topiramate was used as a weight-lowering agent. The patient had fairly stable leukocyte counts for eight months on clozapine 300\u2009mg and topiramate 100\u2009mg daily. Doubling the dosage of topiramate led to severe neutropenia after two months. Reviewing the patient\u2019s laboratory reports showed a gradual decline of neutrophils occurring at a lower dosage, followed by a rapid decline after an increased dosage. In this case, we report that not only did topiramate act as the neutropenic agent, but also it might have done so in a dose-dependent manner.<\/jats:p>","DOI":"10.1155\/2016\/6086839","type":"journal-article","created":{"date-parts":[[2016,1,24]],"date-time":"2016-01-24T21:02:06Z","timestamp":1453669326000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Concomitant Use of Topiramate Inducing Neutropenia in a Schizophrenic Male Stabilized on Clozapine"],"prefix":"10.1155","volume":"2016","author":[{"given":"Pravesh","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivekananda","family":"Rachamallu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Aligeti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Texas Tech University Health Sciences Center, 3601 4th Street, Stop 8103, Lubbock, TX 79430, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2.596"},{"key":"2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00023210-200519010-00001","volume":"19","year":"2005","journal-title":"CNS Drugs"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01416.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e3181fab67d"},{"key":"5","year":"2015"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1056"},{"issue":"4","key":"7","first-page":"35","volume":"8","year":"2011","journal-title":"Innovations in Clinical Neuroscience"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90410-q"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-004-0323-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.11.2008.1273"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629020-00001"}],"container-title":["Case Reports in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2016\/6086839.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2016\/6086839.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2016\/6086839.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T04:25:06Z","timestamp":1498278306000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crips\/2016\/6086839\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":11,"alternative-id":["6086839","6086839"],"URL":"https:\/\/doi.org\/10.1155\/2016\/6086839","relation":{},"ISSN":["2090-682X","2090-6838"],"issn-type":[{"value":"2090-682X","type":"print"},{"value":"2090-6838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}