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Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them. Such functional deficits in hearing without changes in sensitivity are generally called \u201cnoise-induced hidden hearing loss (NIHHL).\u201d Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.<\/jats:p>","DOI":"10.1155\/2016\/6143164","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T21:01:20Z","timestamp":1474491680000},"page":"1-9","source":"Crossref","is-referenced-by-count":65,"title":["Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss"],"prefix":"10.1155","volume":"2016","author":[{"given":"Lijuan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical College of Southeast University, 87 Dingjiaoqiao Road, 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