{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:22:29Z","timestamp":1790346149138,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Surgical Oncology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Malignant peripheral nerve sheath tumours (MPNSTs) are difficult to diagnose and treat and contribute to significant morbidity and mortality for patients with Neurofibromatosis-1 (NF-1). FDG-PET\/CT is being increasingly used as an imaging modality to discriminate between benign and malignant plexiform neurofibromas.\n                    <jats:italic>Objectives<\/jats:italic>\n                    . To assess the value of FDG-PET\/CT in differentiating between benign and malignant peripheral nerve lesions for patients with Neurofibromatosis-1.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A systematic review of the literature was performed prior to application of stringent selection criteria. Ultimately 13 articles with 796 tumours were deemed eligible for inclusion into the review.\n                    <jats:italic>Results<\/jats:italic>\n                    . There was a significant difference between mean\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:msub>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">S<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">U<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">V<\/mml:mi>\n                          <\/mml:mrow>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">m<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">a<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">x<\/mml:mi>\n                          <\/mml:mrow>\n                        <\/mml:msub>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    of benign and malignant lesions (1.93 versus 7.48, resp.). Sensitivity ranged from 89 to 100% and specificity from 72 to 94%. ROC analysis was performed to maximise sensitivity and specificity of\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:msub>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">S<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">U<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">V<\/mml:mi>\n                          <\/mml:mrow>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">m<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">a<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">x<\/mml:mi>\n                          <\/mml:mrow>\n                        <\/mml:msub>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    cut-off; however no clear value was identified (range 3.1\u20136.1). Significant overlap was found between the\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:msub>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">S<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">U<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">V<\/mml:mi>\n                          <\/mml:mrow>\n                          <mml:mrow>\n                            <mml:mi mathvariant=\"normal\">m<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">a<\/mml:mi>\n                            <mml:mi mathvariant=\"normal\">x<\/mml:mi>\n                          <\/mml:mrow>\n                        <\/mml:msub>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    of benign and malignant lesions making differentiation of lesions difficult. Many of the studies suffered from having a small cohort and from not providing histological data on all lesions which underwent FDG-PET\/CT.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . This systematic review is able to demonstrate that FDG-PET\/CT is a useful noninvasive test for discriminating between benign and malignant lesions but has limitations and requires further prospective trials.\n                  <\/jats:p>","DOI":"10.1155\/2016\/6162182","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T18:38:19Z","timestamp":1481567899000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["The Role of [\n                    <sup>18<\/sup>\n                    F]FDG-PET\/CT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-5725","authenticated-orcid":true,"given":"David","family":"Tovmassian","sequence":"first","affiliation":[{"name":"Westmead Hospital, Cnr Hawkesbury and Darcy Rd, Westmead, NSW 2145, Australia"},{"name":"University of Sydney, Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzib","family":"Abdul Razak","sequence":"additional","affiliation":[{"name":"Westmead Hospital, Cnr Hawkesbury and Darcy Rd, Westmead, NSW 2145, Australia"},{"name":"University of Sydney, Camperdown, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"London","sequence":"additional","affiliation":[{"name":"Westmead Hospital, Cnr Hawkesbury and Darcy Rd, Westmead, NSW 2145, Australia"},{"name":"Nuclear Medicine, Westmead Children\u2019s Hospital, Westmead, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1978-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010118"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.0043"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2724"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0523-y"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.01.005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.3.353"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(03)00055-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2060"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm450"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000337597.18599.D3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-1038-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24755"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1386-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0840-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318266ce84"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24212"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-3020-x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.142372"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0954-z"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4923"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.063347"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143305"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-016-2394-7"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151809"}],"container-title":["International Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijso\/2016\/6162182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijso\/2016\/6162182.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijso\/2016\/6162182.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T18:38:19Z","timestamp":1481567899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijso\/2016\/6162182\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"alternative-id":["6162182","6162182"],"URL":"https:\/\/doi.org\/10.1155\/2016\/6162182","relation":{},"ISSN":["2090-1402","2090-1410"],"issn-type":[{"value":"2090-1402","type":"print"},{"value":"2090-1410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}