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DM rat hearts were subjected to 30\u2009min regional ischemia and 120\u2009min reperfusion in vitro and pretreated with ALDH2 activator ethanol (EtOH); cardiomyocyte in high glucose (HG) condition was pretreated with ALDH2 activator Alda\u20101. In control I\/R group, myocardial tissue structure collapse appeared. Compared with control I\/R group, left ventricular parameters, SOD activity, the level of Bcl\u20102\/Bax mRNA, ALDH2 mRNA, and protein expressions were decreased and LDH and MDA contents were increased, meanwhile the aggravation of myocardial structure injury in DM I\/R group. When DM I\/R rats were pretreated with EtOH, left ventricular parameters, SOD, Bcl\u20102\/Bax, and ALDH2 expression were increased; LDH, MDA, and myocardial structure injury were attenuated. Compared with DM + EtOH I\/R group, cyanamide (ALDH2 nonspecific blocker), atractyloside (mitoPTP opener), and wortmannin (PI3K inhibitor) groups all decreased left ventricular parameters, SOD, Bcl\u20102\/Bax, and ALDH2 and increased LDH, MDA, and myocardial injury. When cardiomyocyte was under HG condition, CCK\u20108 activity and ALDH2 protein expression were decreased. Alda\u20101 increased CCK\u20108 and ALDH2. Our findings suggested enhanced ALDH2 expression in diabetic I\/R rats played the cardioprotective role, maybe through activating PI3K and inhibiting mitoPTP opening.<\/jats:p>","DOI":"10.1155\/2016\/6190504","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T21:24:16Z","timestamp":1476825856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial Ischemia\/Reperfusion Injury in Diabetes Rat Model"],"prefix":"10.1155","volume":"2016","author":[{"given":"Pin-Fang","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Dong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-4295","authenticated-orcid":false,"given":"Qin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-6451","authenticated-orcid":false,"given":"Hong-Ju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1372.029"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32833552bc"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679597"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.06.019"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.05.008"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470511848.ch5"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2009.09.003"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.06.011"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.012"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.100"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.823799"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.08.002"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.09.713"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158554"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.10.030"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00114"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1524"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.906610"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-007-0723-y"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp151"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102108-134850"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.09.017"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.04.022"},{"key":"e_1_2_8_24_2","first-page":"566","article-title":"Activation of mitochondrial aldehyde dehydrogenase 2 and inhibition of mitochondrial permeability transition pore involved in cardioprotection of ethanol postconditioning","volume":"39","author":"Li Z. 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