{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:03:45Z","timestamp":1774375425109,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare the long-term outcomes of infectious versus sterile perforated corneal ulcers after therapeutic penetrating keratoplasty in the United States.<jats:italic>Methods<\/jats:italic>. The charts of 45 consecutive eyes that underwent primary therapeutic penetrating keratoplasty for a perforated corneal ulcer at a single center were retrospectively reviewed. The perforated ulcers were classified as infectious or sterile and the underlying demographics, clinical features, and 36-month outcomes were compared among the two groups.<jats:italic>Results.<\/jats:italic>Mean follow-up among subjects was 38.6 (\u00b16.9) months. Patients presenting with sterile perforated ulcers were more likely to have a peripheral perforation location (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0333<\/mml:mn><\/mml:math>) and recurrence of the underlying disease condition (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0321<\/mml:mn><\/mml:math>), require adjunctive surgical measures in the immediate postoperative period (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0001<\/mml:mn><\/mml:math>), have reperforation after keratoplasty (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0079<\/mml:mn><\/mml:math>), have worse best corrected visual acuity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0130<\/mml:mn><\/mml:math>), develop no light perception vision (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0053<\/mml:mn><\/mml:math>), and require enucleation\/evisceration (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0252<\/mml:mn><\/mml:math>) when compared to the infectious perforated ulcer group.<jats:italic>Conclusions<\/jats:italic>. Sterile perforated corneal ulcers have a worse prognosis and may be more frequent than those caused by infectious disease in the United States compared to the developing world.<\/jats:p>","DOI":"10.1155\/2016\/6284595","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T16:03:51Z","timestamp":1481645031000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of Infectious versus Sterile Perforated Corneal Ulcers after Therapeutic Penetrating Keratoplasty in the United States"],"prefix":"10.1155","volume":"2016","author":[{"given":"Sloan W.","family":"Rush","sequence":"first","affiliation":[{"name":"Panhandle Eye Group, 7400 Fleming Ave., Amarillo, TX 79106, USA"},{"name":"Texas Tech University Health Sciences Center, 1400 S. 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