{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:09:57Z","timestamp":1793333397614,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Project of the Charles University in Prague","award":["PRVOUK P35"],"award-info":[{"award-number":["PRVOUK P35"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Surgical correction of mitral regurgitation (MR) can lead to postoperative low cardiac output state. We aimed to assess the acute hemodynamic changes after percutaneous MitraClip therapy (a unique model without influence of factors linked to surgical procedure) in patients with functional MR without the influence of general anaesthesia.<jats:italic> Methods<\/jats:italic>. We studied invasive hemodynamic parameters in 23 patients before procedure (conscious, nonsedated patients), during procedure (intubated patients), and the first day after MitraClip implantation (conscious, extubated patients).<jats:italic> Results<\/jats:italic>. Mitral valve clipping significantly increased cardiac index (CI) (from 2.0 \u00b1 0.5 to 3.3 \u00b1 0.6\u2009L\/min\/m<jats:sup>2<\/jats:sup>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>). Conversely, there was significant reduction in the mean pulmonary capillary wedge pressure (PCWP) (from 18.6 \u00b1 5.7 to 10.5 \u00b1 3.8\u2009mmHg; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>), mean pulmonary artery pressure (from 29.8 \u00b1 10.9 to 25.2 \u00b1 10.3\u2009mmHg; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.03<\/mml:mn><\/mml:math>), and pulmonary vascular resistance index (from 531 \u00b1 359 to 365 \u00b1 193\u2009dyn\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup>\/m<jats:sup>2<\/jats:sup>; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.03<\/mml:mn><\/mml:math>).<jats:italic> Conclusions<\/jats:italic>. The functional MR therapy with percutaneous MitraClip device results in significant increase in CI (+66%) and concomitant decrease in PCWP (\u221242%). None of our patients developed low cardiac output state. Our results support the idea that significant part of low cardiac output state after cardiac surgery is due to surgery related factors rather than due to increase in afterload after MR elimination.<\/jats:p>","DOI":"10.1155\/2016\/6296972","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T18:40:14Z","timestamp":1481568014000},"page":"1-7","source":"Crossref","is-referenced-by-count":9,"title":["Invasive Hemodynamic Assessment of Cardiac Output State after MitraClip Therapy in Nonanaesthetized Patients with Functional Mitral Regurgitation"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-2575","authenticated-orcid":true,"given":"Frantisek","family":"Bednar","sequence":"first","affiliation":[{"name":"Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic"},{"name":"Department of Cardiology, University Hospital Kralovske Vinohrady, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Budesinsky","sequence":"additional","affiliation":[{"name":"Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic"},{"name":"Department of Cardiology, University Hospital Kralovske Vinohrady, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Linkova","sequence":"additional","affiliation":[{"name":"Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic"},{"name":"Department of Cardiology, University Hospital Kralovske Vinohrady, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-0545","authenticated-orcid":true,"given":"Viktor","family":"Kocka","sequence":"additional","affiliation":[{"name":"Cardiocenter, Third Faculty of Medicine, Charles University, Prague, Czech Republic"},{"name":"Department of Cardiology, University Hospital Kralovske Vinohrady, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.4.1022"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.99.3.400"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.619239"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.043"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300705"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.135061"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.07.015"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3934842"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.230839"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.067"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.062"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.021"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/6296972.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/6296972.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/6296972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T18:40:18Z","timestamp":1481568018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2016\/6296972\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":13,"alternative-id":["6296972","6296972"],"URL":"https:\/\/doi.org\/10.1155\/2016\/6296972","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}