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Here, we studied the mechanisms underlying its treatment effects, especially its anti\u2010inflammatory effects in a collagen\u2010induced arthritis (CIA) mouse model. We found that cartilage destruction and pannus formation were alleviated by treatment with XFHM. The abnormal differentiation of Th1 and Th17 cells was downregulated significantly by XFHM, and Th2 and Treg cells were upregulated. Moreover, the expression levels of specific cytokines and transcription factors related to Th1 cells (interferon <jats:italic>\u03b3<\/jats:italic> [IFN<jats:italic>\u03b3<\/jats:italic>], T\u2010bet) and Th17 cells (interleukin\u2010 [IL\u2010] 17) and the nuclear receptor retinoic acid receptor\u2010related orphan receptor\u2010gamma (ROR<jats:italic>\u03b3<\/jats:italic>) were downregulated. Serum IL\u20104 and GATA\u20103, which contribute to Th2 cells differentiation, increased significantly after XFHM administration. These results indicate that XFHM can restore the balance of T lymphocytes and reestablish the immunological tolerance to inhibit autoinflammatory disorder of RA. Taken together, XFHM can be used as a complementary or alternative traditional medicine to treat RA.<\/jats:p>","DOI":"10.1155\/2016\/6356871","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T22:28:47Z","timestamp":1472596127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen\u2010Induced Arthritis Mouse Model"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-3542","authenticated-orcid":false,"given":"Bo","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-7776","authenticated-orcid":false,"given":"Lixia","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-5532","authenticated-orcid":false,"given":"Aiming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-8728","authenticated-orcid":false,"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingqun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-0416","authenticated-orcid":false,"given":"Jiuli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9207-1169","authenticated-orcid":false,"given":"Limin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2358"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0047"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1004965"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311239111"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.205"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.149"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0907-903"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.179"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21195"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep13982"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0821-2"},{"key":"e_1_2_8_14_2","first-page":"199","article-title":"Xianfang huoming decoction jiawei iontophoresis analysis combined with clinical of arthroscopic debridement for osteoarthritis of kneei","volume":"20","author":"Zeng J.-F.","year":"2014","journal-title":"Chinese Journal of Experimental Traditional Medical Formulae"},{"key":"e_1_2_8_15_2","article-title":"Clinical observation on the treatment of hip joint synovitis in children with internal and external application of Xianfang Huoming Yin","volume":"4","author":"Gao Xuan D. 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