{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:43:23Z","timestamp":1780069403679,"version":"3.54.0"},"reference-count":32,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI.<jats:italic>Methods<\/jats:italic>. The clinical, hormonal, and neuroradiological characteristics of children with CDI at diagnosis and during 1.5\u20132-year follow-up were collected and analyzed.<jats:italic>Results<\/jats:italic>. The study included 43 CDI patients. The mean interval between initial manifestation and diagnosis was 22.29 \u00b1 3.67 months (range: 2\u2013108 months). The most common complaint was polyuria\/polydipsia. Causes included Langerhans cell histiocytosis, germinoma, and craniopharyngioma in 2, 5, and 4 patients; the remaining were idiopathic. No significant changes were found during the 1.5\u20132 years after CDI diagnosis. Twenty-three of the 43 cases (53.5%) had \u22651 anterior pituitary hormone deficiency. Isolated growth hormone deficiency was the most frequent abnormality (37.5%) and was not associated with pituitary stalk diameter. Multiple pituitary hormone deficiencies were found in 8 cases with pituitary stalk diameter &gt; 4.5\u2009mm.<jats:italic>Conclusion<\/jats:italic>. Diagnosis of CDI is usually delayed. CDI with a pituitary stalk diameter &gt; 4.5\u2009mm carries a higher risk of multiple pituitary hormone deficiencies. Long-term MRI and pituitary function follow-ups are necessary for children with idiopathic CDI.<\/jats:p>","DOI":"10.1155\/2016\/6365830","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T22:47:24Z","timestamp":1459291644000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus"],"prefix":"10.1155","volume":"2016","author":[{"given":"Wendong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China"},{"name":"Department of Pediatrics, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 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