{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:58:01Z","timestamp":1789905481016,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alcon Laboratories Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate accuracy of various Keratoconus (KC) screening indices, in relation to Topographic Keratoconus (TKC) grading.<jats:italic>Setting<\/jats:italic>. Al Watany Eye Hospital, Cairo, Egypt.<jats:italic>Methods.<\/jats:italic>Data of 103 normal (<jats:italic>group 1<\/jats:italic>) and 73 KC eyes (<jats:italic>group 2<\/jats:italic>), imaged by Pentacam (branded as Allegro Oculyzer), were analysed.<jats:italic>Group 2<\/jats:italic>was divided into<jats:italic>2a<\/jats:italic>: 14 eyes (TKC = 1, early KC),<jats:italic>2b<\/jats:italic>: 25 eyes (TKC = 1 to 2 or 2, moderate KC), and<jats:italic>2c<\/jats:italic>: 34 eyes (TKC = 2 to 3 up to 4, severe KC). Participants were followed up for six years to confirm diagnosis. Area under the receiver operating characteristic curve (AUROC) was calculated for evaluated curvature, elevation, and pachymetry indices with various reference shapes at different diameters.<jats:italic>Results<\/jats:italic>. When comparing normal to KC eyes, ten indices had significantly higher AUROC. Only five of them had significantly higher AUROC in early KC compared to normal corneas: Pachymetry Progression Index- (PPI-) Maximum (Max), Ambr\u00f3sio\u2019s Relational Thickness- (ART-) Max, PPI-Max minus PPI-Minimum (Min), central corneal thickness (CCT), and diagonal decentration of thinnest point from the apex (AUROC = 0.690, 0.690, 0.687, 0.683, and 0.674, resp.).<jats:italic>Conclusion<\/jats:italic>. Generally, ten pachymetry and elevation-based indices had significantly higher AUROC. Five indices had statistically significant high AUROC when comparing early KC to normal corneas.<\/jats:p>","DOI":"10.1155\/2016\/6392472","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T21:01:23Z","timestamp":1470690083000},"page":"1-9","source":"Crossref","is-referenced-by-count":30,"title":["Rotating Scheimpflug Imaging Indices in Different Grades of Keratoconus"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-7249","authenticated-orcid":true,"given":"Sherine S.","family":"Wahba","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt"},{"name":"Al Watany Eye Hospitals, 211 Alhegaz Street, Alhegaz Square, Heliopolis, Cairo 11361, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-8623","authenticated-orcid":true,"given":"Maged 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