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Huntington\u2019s disease is caused by a polyglutamate expansion of the protein huntingtin. Aberrant huntingtin is less capable of binding to a member of membrane-associated guanylate kinase family (MAGUKs): postsynaptic density- (PSD-) 95. This leaves more PSD-95 available to stabilize NR2B subunit carrying NMDA receptors in the synaptic membrane. This results in increased excitotoxicity for which particularly striatal medium spiny neurons from the indirect extrapyramidal pathway are sensitive. In Parkinson\u2019s disease the sensitivity for excitotoxicity is related to increased oxidative stress due to genetically determined abnormal metabolism of dopamine or related products. This probably also increases the sensitivity of medium spiny neurons for exogenous levodopa. Particularly the combination of increased oxidative stress due to aberrant dopamine metabolism, increased vulnerability to NMDA induced excitotoxicity, and the particular sensitivity of indirect pathway medium spiny neurons for this excitotoxicity may explain the observed increased prevalence of levodopa-induced dyskinesia.<\/jats:p>","DOI":"10.1155\/2016\/6461907","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T20:37:47Z","timestamp":1459975067000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected Finding"],"prefix":"10.1155","volume":"2016","author":[{"given":"Svetlana A.","family":"Ivanova","sequence":"first","affiliation":[{"name":"Mental Health Research Institute, Tomsk, Russia"},{"name":"National Research Tomsk Polytechnic University, Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4942-6195","authenticated-orcid":true,"given":"Anton J. 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