{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:51:00Z","timestamp":1789642260018,"version":"4.0.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. To investigate the climb stairs resistance exercise on nociception and axonal regeneration in the sciatic nerve of rats.<jats:italic>Methods<\/jats:italic>. 24 Wistar rats were divided: control group (CG\u2014no injury), exercise group (EG\u2014no injury with physical exercise), lesion group (LG\u2014injury, but without exercise), and treated group (LEG\u2014injury and physical exercise). LG and LEG were subjected to sciatic nerve compression with hemostat. From the 3rd day after injury began treatment with exercise, and after 22 days occurs the removal of a nerve fragment for morphological analysis.<jats:italic>Results<\/jats:italic>. Regarding allodynia, CG obtained values less than EG<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.012<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>and larger than LG and LEG<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Histological results showed that CG and EG had normal appearance, as LG and LEG showed up with large amounts of inflammatory infiltration, degeneration and disruption of nerve fibers, and reduction of the myelin sheath; however LEG presented some regenerated fibers. From the morphometric data there were significant differences, for nerve fiber diameter, comparing CG with LG and LEG and comparing axon diameter and the thickness of the myelin of the CG to others.<jats:italic>Conclusion<\/jats:italic>. Climb stairs resistance exercise was not effective to speed up the regenerative process of axons.<\/jats:p>","DOI":"10.1155\/2016\/6487160","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T17:04:33Z","timestamp":1470848673000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Nociceptive and Neuronal Evaluation of the Sciatic Nerve of Wistar Rats Subjected to Compression Injury and Treated with Resistive Exercise"],"prefix":"10.1155","volume":"2016","author":[{"given":"Juliana Sobral","family":"Antunes","sequence":"first","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"Lovison","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhenifer","family":"Karvat","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Peretti","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizyana","family":"Vieira","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Hideaki","family":"Higuchi","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-5076","authenticated-orcid":true,"given":"Rose Meire Costa","family":"Brancalh\u00e3o","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucin\u00e9ia de F\u00e1tima Chasko","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. Box 711, 85819-110 Cascavel, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-2019","authenticated-orcid":true,"given":"Gladson Ricardo Flor","family":"Bertolini","sequence":"additional","affiliation":[{"name":"State University of Western Paran\u00e1 (UNIOESTE), Universitaria Street, 2069, P.O. 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