{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:01:20Z","timestamp":1761156080091,"version":"3.37.3"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["167737","201509"],"award-info":[{"award-number":["167737","201509"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["167737","201509"],"award-info":[{"award-number":["167737","201509"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Cell wall (CW) components of fungus<jats:italic>Sporothrix schenckii<\/jats:italic>are the major inductors antigens of immune responses. The immunodominant 60\u2009kDa glycoprotein (gp60) has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown. In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL\/6 and BALB\/c mice strains which were then infected with<jats:italic>S. schenckii<\/jats:italic>conidia. Results showed that both mice strains use different cytokine profiles in order to fight<jats:italic>S. schenckii<\/jats:italic>infection; C57BL\/6 mice seem to use a Th17 response while BALB\/c mice tend to depend on a Th1 profile. Preimmunization with gp60 showed a downregulatory effect on the immune response since cytokines levels were diminished in both strains. There were no significant differences in the magnitude of dorsoplantar inflammation between gp60-preimmunized and nonimmunized mice of both strains. However, skin lesions due to the infection in gp60-preimmunized mice were more severe in BALB\/c than in C57BL\/6 mice, suggesting that the antigen exerts a higher downregulatory effect on the Th1 response.<\/jats:p>","DOI":"10.1155\/2016\/6525831","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T21:01:37Z","timestamp":1457989297000},"page":"1-15","source":"Crossref","is-referenced-by-count":9,"title":["Immune Response Induced by an Immunodominant 60\u2009kDa Glycoprotein of the Cell Wall of<i>Sporothrix schenckii<\/i>in Two Mice Strains with Experimental Sporotrichosis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Carlos A.","family":"Alba-Fierro","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Universidad Ju\u00e1rez del Estado de Durango, Avenida Veterinaria S\/N, 34120 Durango, DGO, 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