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Molecular studies of coexisting<jats:italic>JAK2<\/jats:italic>V617F-positive myeloproliferative neoplasms and mature B cell malignancies indicate distinct disease entities arising in myeloid and lymphoid committed hematopoietic progenitor cells, respectively. Mutations of<jats:italic>CALR<\/jats:italic>in essential thrombocythemia appear to be associated with a distinct phenotype and a lower risk of thrombosis yet their impact on disease progression is less well defined. The as yet undescribed scenario of pro-B cell acute lymphoblastic leukemia arising in<jats:italic>CALR<\/jats:italic>mutated essential thrombocythemia is presented. Intensive treatment for the leukemia allowed for expansion of the original<jats:italic>CALR<\/jats:italic>mutated clone. Whether<jats:italic>CALR<\/jats:italic>mutations in myeloproliferative neoplasms predispose to the acquisition of additional malignancies, particularly lymphoproliferative disorders, is not yet known.<\/jats:p>","DOI":"10.1155\/2016\/6545861","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T21:03:28Z","timestamp":1453410208000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Acute Lymphoblastic Leukemia Arising in<i>CALR<\/i>Mutated Essential Thrombocythemia"],"prefix":"10.1155","volume":"2016","author":[{"given":"Stephen E.","family":"Langabeer","sequence":"first","affiliation":[{"name":"Cancer Molecular Diagnostics, St. James\u2019s Hospital, Dublin 8, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Haslam","sequence":"additional","affiliation":[{"name":"Cancer Molecular Diagnostics, St. James\u2019s Hospital, Dublin 8, 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