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Mutations in MYH14 lead to a DFNA4-type hearing impairment. Further evidence also shows that MYH14 is a candidate noise-induced hearing loss (NIHL) susceptible gene. However, the specific roles of MYH14 in auditory function and NIHL are not fully understood. In the present study, we used CRISPR\/Cas9 technology to establish a Myh14 knockout mice line in CBA\/CaJ background (now referred to as Myh14<jats:sup>\u2212\/\u2212<\/jats:sup>mice) and clarify the role of MYH14 in the cochlea and NIHL. We found that Myh14<jats:sup>\u2212\/\u2212<\/jats:sup>mice did not exhibit significant hearing loss until five months of age. In addition, Myh14<jats:sup>\u2212\/\u2212<\/jats:sup>mice were more vulnerable to high intensity noise compared to control mice. More significant outer hair cell loss was observed in Myh14<jats:sup>\u2212\/\u2212<\/jats:sup>mice than in wild type controls after acoustic trauma. Our findings suggest that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA\/CaJ mice.<\/jats:p>","DOI":"10.1155\/2016\/6720420","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T14:47:55Z","timestamp":1482504475000},"page":"1-16","source":"Crossref","is-referenced-by-count":29,"title":["Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA\/CaJ Mice"],"prefix":"10.1155","volume":"2016","author":[{"given":"Xiaolong","family":"Fu","sequence":"first","affiliation":[{"name":"School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 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