{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T18:23:22Z","timestamp":1750875802480},"reference-count":23,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health of Czech Republic","award":["NT\/13198"],"award-info":[{"award-number":["NT\/13198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate &lt; 60\u2009mL\/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss \u2265 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR &lt;\/\u226565 (arbitrary cut-off) and 75 (median) bpm were not found. We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic.<\/jats:p>","DOI":"10.1155\/2016\/6726492","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T21:04:31Z","timestamp":1451336671000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients"],"prefix":"10.1155","volume":"2016","author":[{"given":"Vendula","family":"Bart\u00e1kov\u00e1","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Klime\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Medical Faculty, Masaryk University Brno, Kamenice 5, 62500 Brno, Czech 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