{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:13:30Z","timestamp":1790216010678,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"\n Objective<\/jats:italic>\n . To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients.\n Methods<\/jats:italic>\n . 464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA,\n \n n<\/mml:mi>\n =<\/mml:mo>\n 157<\/mml:mn>\n <\/mml:math>\n ), microalbuminuria group (MA,\n \n n<\/mml:mi>\n =<\/mml:mo>\n 159<\/mml:mn>\n <\/mml:math>\n ), and large amount of albuminuria group (LA,\n \n n<\/mml:mi>\n =<\/mml:mo>\n 148<\/mml:mn>\n <\/mml:math>\n ). 127 healthy persons were selected as the control group (NC,\n \n n<\/mml:mi>\n =<\/mml:mo>\n 127<\/mml:mn>\n <\/mml:math>\n ). The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor-\n \u03b2<\/jats:italic>\n 1 (TGF-\n \u03b2<\/jats:italic>\n 1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay. The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis.\n Results<\/jats:italic>\n . The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.01<\/mml:mn>\n <\/mml:math>\n ). The TGF-\n \u03b2<\/jats:italic>\n 1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.01<\/mml:mn>\n <\/mml:math>\n ). The expression of miR-192 was negatively correlated with TGF-\n \u03b2<\/jats:italic>\n 1, FN, and Ln (UACR) and miR-192, TGF-\n \u03b2<\/jats:italic>\n 1, and FN were independent relevant factors affecting Ln (UACR) in T2DM (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.01<\/mml:mn>\n <\/mml:math>\n ).\n Conclusions<\/jats:italic>\n . These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.\n <\/jats:p>","DOI":"10.1155\/2016\/6789402","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T16:05:14Z","timestamp":1452009914000},"page":"1-6","source":"Crossref","is-referenced-by-count":45,"title":["The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio"],"prefix":"10.1155","volume":"2016","author":[{"given":"Xiaoyu","family":"Ma","sequence":"first","affiliation":[{"name":"Geriatrics Department, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canlu","family":"Lu","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Endocrine Department, The People Hospital of Liaoning Province, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Wu","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrine Department, The First Hospital of China Medical University, Shenyang, Liaoning, 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