{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:59:47Z","timestamp":1755694787967,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Sarcoidosis is a rare multisystemic granulomatous inflammatory disease of unknown etiology affecting the respiratory system, skin, and eyes. Sarcoidosis outside the lacrimal gland is rare. The case study concerns a patient with a final diagnosis of orbital sarcoidosis.<jats:italic>Case Report<\/jats:italic>. A 37-year-old male patient went to the ophthalmic emergency room complaining of pain in the left eye, diplopia, and decreased visual acuity. An external eye examination showed hard and cold edema of the lower eyelid, ocular motility with limitation of adduction, and discreet ipsilateral proptosis. Magnetic resonance of the orbit showed left eye proptosis and thickening and increase of soft tissues associated with heterogeneous impregnation of contrast in the infralateral region of the left eyelid. A biopsy of the lesion showed a chronic inflammatory process, with numerous compact nonnecrotizing granulomas surrounded by lamellar hyaline collagen, providing histological confirmation of sarcoidosis.<jats:italic>Discussion<\/jats:italic>. A biopsy of the orbital tumor is essential for the diagnosis of sarcoidosis, in addition to the search for systemic findings such as hilar adenopathy or parenchymal lung disease found in 90% of patients.<\/jats:p>","DOI":"10.1155\/2016\/6912927","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T08:03:00Z","timestamp":1463731380000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Unilateral Eyelid Edema as Initial Sign of Orbital Sarcoidosis"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2555-0108","authenticated-orcid":true,"given":"S\u00edlvia Migu\u00e9is Picado","family":"Petrarolha","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Hospital Ana Costa, 11050-120 Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-483X","authenticated-orcid":true,"given":"Bruna Suda","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Metropolitana de Santos (UNIMES), 11050-120 Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio David Haddad","family":"Filho","sequence":"additional","affiliation":[{"name":"Universidade Metropolitana de Santos (UNIMES), 11050-120 Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio Aparecido","family":"Dedivitis","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo School of Medicine, S\u00e3o Paulo, SP, Brazil"},{"name":"Department of Head and Neck Surgery, Hospital Ana Costa, Santos and Irmandade da Santa Casa da Miseric\u00f3rdia, 11050-120 Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Brunini","family":"Petrarolha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Ana Costa, 11050-120 Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-1851","authenticated-orcid":true,"given":"Pedro Martins Tavares Scianni","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Ana Costa, 11050-120 Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.6.804"},{"issue":"7","key":"2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0929-693X(96)87093-X","volume":"3","year":"1996","journal-title":"Archives de P\u00e9diatrie"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702383"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30378-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker432"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2015.12.008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3980\/j.issn.2222-3959.2015.06.35"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000207"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8479-6"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147258"},{"issue":"2","key":"12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4081\/reumatismo.2015.832","volume":"67","year":"2015","journal-title":"Reumatismo"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ccm.2015.08.009","volume":"36","year":"2015","journal-title":"Clinics in Chest Medicine"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/6912927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/6912927.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/6912927.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T21:40:40Z","timestamp":1656452440000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2016\/6912927\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":12,"alternative-id":["6912927","6912927"],"URL":"https:\/\/doi.org\/10.1155\/2016\/6912927","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2016]]}}}