{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:59:13Z","timestamp":1776448753936,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Complex regional pain syndrome (CRPS) after fracture is a cause of pain, dysfunction, and potentially permanent disability. The evidence for treatment with oral corticosteroids is growing and supported by several international guidelines; however, treatment is not widely offered.<jats:italic>Objective<\/jats:italic>. Rapid recognition and treatment of complex regional pain in the upper extremity after acute injury as a disease modifying and potentially curative treatment.<jats:italic>Methods<\/jats:italic>. The present study was a case series involving three patients who developed CRPS after a trauma to the neck and\/or upper limb. Patients were screened by clinical examination and bone scan and met the Budapest criteria.<jats:italic>Results<\/jats:italic>. Resolution of pain, swelling, and disability in all three patients.<jats:italic>Discussion<\/jats:italic>. There is increasing support, based on the existing evidence and clinical outcomes, for the use of prednisone to treat the acute phase of CRPS and as a promising treatment to halt the progression of the phenomenon and potentially cure the condition; however, widespread use of prednisone likely remains low, potentially resulting in long-term pain, joint contracture, and disability. A large-scale randomized control trial has not been performed.<jats:italic>Conclusion<\/jats:italic>. Corticosteroids can be an effective treatment option for CRPS after fracture.<\/jats:p>","DOI":"10.1155\/2016\/7019196","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T17:00:50Z","timestamp":1462035650000},"page":"1-5","source":"Crossref","is-referenced-by-count":20,"title":["Early Treatment of Acute Complex Regional Pain Syndrome after Fracture or Injury with Prednisone: Why Is There a Failure to Treat? 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