{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:51:54Z","timestamp":1785865914912,"version":"3.56.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and\/or acne scars. The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls. Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting. Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-\/PI3K-\/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.<\/jats:p>","DOI":"10.1155\/2016\/7040312","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T21:09:07Z","timestamp":1476133747000},"page":"1-8","source":"Crossref","is-referenced-by-count":21,"title":["Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I"],"prefix":"10.1155","volume":"2016","author":[{"given":"Hanan A.","family":"Assaf","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Sohag University, P.O. 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