{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:59:11Z","timestamp":1776895151577,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005983","name":"Department of Trade and Industry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005983","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000277","name":"Department for Environment, Food and Rural Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>As lifetime exposure to ultraviolet (UV) radiation has risen, the deleterious effects have also become more apparent. Numerous sunscreen and skincare products have therefore been developed to help reduce the occurrence of sunburn, photoageing, and skin carcinogenesis. This has stimulated research into identifying new natural sources of effective skin protecting compounds. Alkaline single\u2010cell gel electrophoresis (comet assay) was employed to assess aqueous extracts derived from soil or hydroponically glasshouse\u2010grown roots of <jats:italic>Althea officinalis<\/jats:italic> (Marshmallow) and <jats:italic>Astragalus membranaceus<\/jats:italic>, compared with commercial, field\u2010grown roots. Hydroponically grown root extracts from both plant species were found to significantly reduce UVA\u2010induced DNA damage in cultured human lung and skin fibroblasts, although initial <jats:italic>Astragalus<\/jats:italic> experimentation detected some genotoxic effects, indicating that <jats:italic>Althea<\/jats:italic> root extracts may be better suited as potential constituents of dermatological formulations. Glasshouse\u2010grown soil and hydroponic <jats:italic>Althea<\/jats:italic> root extracts afforded lung fibroblasts with statistically significant protection against UVA irradiation for a greater period of time than the commercial field\u2010grown roots. No significant reduction in DNA damage was observed when total ultraviolet irradiation (including UVB) was employed (data not shown), indicating that the extracted phytochemicals predominantly protected against indirect UVA\u2010induced oxidative stress. <jats:italic>Althea<\/jats:italic> phytochemical root extracts may therefore be useful components in dermatological formulations.<\/jats:p>","DOI":"10.1155\/2016\/7053897","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T21:02:48Z","timestamp":1454533368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["An Evaluation of Root Phytochemicals Derived from <i>Althea officinalis<\/i> (Marshmallow) and <i>Astragalus membranaceus<\/i> as Potential Natural Components of UV Protecting Dermatological Formulations"],"prefix":"10.1155","volume":"2016","author":[{"given":"Alison","family":"Curnow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara J.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"key":"e_1_2_7_1_2","volume-title":"Cancer Statistics Report: Skin Cancer","author":"Cancer Research UK","year":"2013"},{"key":"e_1_2_7_2_2","volume-title":"Cancer Registration Statistics","author":"Office for National Statistics","year":"2015"},{"key":"e_1_2_7_3_2","series-title":"Studies on Medical and Population Subjects","volume-title":"Cancer Trends in England and Wales 1950\u20131999","author":"Quinn M. 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