{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:57:06Z","timestamp":1774969026226,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>We compared the presence of diverse cytokines and regulatory T and B cells in skin biopsies of discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE). We included 19 patients with DLE, 13 with SCLE, 8 healthy controls, and 5 patients with hypertrophic scars. We assessed the CLASI activity score. To determine IL-22-producing cells and the subpopulation of CD4<jats:sup>+<\/jats:sup>\/IL-17A<jats:sup>+<\/jats:sup>-, CD4<jats:sup>+<\/jats:sup>\/IL-4<jats:sup>+<\/jats:sup>-, and CD4<jats:sup>+<\/jats:sup>\/IFN-<jats:italic>\u03b3<\/jats:italic><jats:sup>+<\/jats:sup>-expressing T cells, CD123<jats:sup>+<\/jats:sup>\/IDO<jats:sup>+<\/jats:sup>pDCs, CD25<jats:sup>+<\/jats:sup>\/Foxp3<jats:sup>+<\/jats:sup>Tregs, and CD20<jats:sup>+<\/jats:sup>\/IL-10<jats:sup>+<\/jats:sup>-producing B cells, an immunostaining procedure was performed. Also intracellular IL-22, IL-17, IL-4, IFN-<jats:italic>\u03b3<\/jats:italic>, and Foxp3 in CD4 T cells, IL-10 in B cells, and IDO in pDCs were analyzed by flow cytometry in peripheral blood. The main cellular participation in both lupus groups was IL-17- and IL-22-producing cell responses both at skin and at peripheral blood but prevailed in DLE. The CLASI activity scores negatively correlated with Th22 subpopulation and positively correlated with CD25<jats:sup>+<\/jats:sup>\/Foxp3<jats:sup>+<\/jats:sup>Treg cells. In conclusion a proinflammatory and regulatory imbalance coexists in cutaneous lupus, both responses being more intense in DLE.<\/jats:p>","DOI":"10.1155\/2016\/7074829","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T16:01:10Z","timestamp":1457280070000},"page":"1-15","source":"Crossref","is-referenced-by-count":28,"title":["Cytokines and Effector\/Regulatory Cells Characterization in the Physiopathology of Cutaneous Lupus Erythematous: A Cross-Sectional Study"],"prefix":"10.1155","volume":"2016","author":[{"given":"Silvia","family":"M\u00e9ndez-Flores","sequence":"first","affiliation":[{"name":"Department of Dermatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Hern\u00e1ndez-Molina","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Bety","family":"Enr\u00edquez","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Faz-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeraldin","family":"Esquivel","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Pacheco-Molina","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-7221","authenticated-orcid":true,"given":"Janette","family":"Furuzawa-Carballeda","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Vasco de Quiroga No. 15, Colonia Belisario Dominguez Secci\u00f3n XVI, 14080 Mexico City, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26581-3_14"},{"key":"2","first-page":"34","volume":"6","year":"1977","journal-title":"Continuing Medical Education Family Physicians"},{"key":"3","first-page":"552","volume-title":"Pathomechanisms of cutaneous lupus erythematosus","year":"2007"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1995.tb00222.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(97)70279-2"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03996.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13123"},{"issue":"9, article 1725","key":"8","volume":"40","year":"1997","journal-title":"Arthritis and Rheumatism"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202x.2005.23889.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12224"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02491.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9365-x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1172\/jci40202"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.11.009"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.09.007"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9878-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12135"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.08.016"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/ni1552"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2008.04.017"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.11.004"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.03.004"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01237.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.185"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1467"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/bf00920636"},{"issue":"8","key":"28","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L","volume":"42","year":"1999","journal-title":"Arthritis & Rheumatism"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.04.009"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/art.21034"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.269"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/nri3831"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1932"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/art.22699"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202027"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00121-5"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.044974"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-72005-0_12"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2579"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21944"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900408106"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.02.11"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.009"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0262-6"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02806.x"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9111-1"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12330"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/7074829.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/7074829.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/7074829.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T03:45:54Z","timestamp":1498275954000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/mi\/2016\/7074829\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":47,"alternative-id":["7074829","7074829"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7074829","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}