{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:32:18Z","timestamp":1768433538128,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330080"],"award-info":[{"award-number":["81330080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173054"],"award-info":[{"award-number":["81173054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZDSYS14005"],"award-info":[{"award-number":["ZDSYS14005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["14JC1401100"],"award-info":[{"award-number":["14JC1401100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330080"],"award-info":[{"award-number":["81330080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173054"],"award-info":[{"award-number":["81173054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZDSYS14005"],"award-info":[{"award-number":["ZDSYS14005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["14JC1401100"],"award-info":[{"award-number":["14JC1401100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["81330080"],"award-info":[{"award-number":["81330080"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["81173054"],"award-info":[{"award-number":["81173054"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["ZDSYS14005"],"award-info":[{"award-number":["ZDSYS14005"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["14JC1401100"],"award-info":[{"award-number":["14JC1401100"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["81330080"],"award-info":[{"award-number":["81330080"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["81173054"],"award-info":[{"award-number":["81173054"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["ZDSYS14005"],"award-info":[{"award-number":["ZDSYS14005"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14JC1401100"],"award-info":[{"award-number":["14JC1401100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Endothelium\u2010dependent vasorelaxant injury leads to a lot of cardiovascular diseases. Both hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) and nitric oxide (NO) are gasotransmitters, which play a critical role in regulating vascular tone. However, the interaction between H<jats:sub>2<\/jats:sub>S and NO in vasorelaxation is still unclear. ZYZ\u2010803 was a novel H<jats:sub>2<\/jats:sub>S and NO conjugated donor developed by H<jats:sub>2<\/jats:sub>S\u2010releasing moiety (<jats:italic>S<\/jats:italic>\u2010propyl\u2010L\u2010cysteine (SPRC)) and NO\u2010releasing moiety (furoxan). ZYZ\u2010803 could time\u2010 and dose\u2010dependently relax the sustained contraction induced by PE in rat aortic rings, with potencies of 1.5\u2010 to 100\u2010fold greater than that of furoxan and SPRC. Inhibition of the generations of H<jats:sub>2<\/jats:sub>S and NO with respective inhibitors abolished the vasorelaxant effect of ZYZ\u2010803. ZYZ\u2010803 increased cGMP level and the activity of vasodilator stimulated phosphoprotein (VASP) in aortic rings, and those effects could be suppressed by the inhibitory generation of H<jats:sub>2<\/jats:sub>S and NO. Both the inhibitor of protein kinase G (KT5823) and the inhibitor of K<jats:sub>ATP<\/jats:sub> channel (glibenclamide) suppressed the vasorelaxant effect of ZYZ\u2010803. Our results demonstrated that H<jats:sub>2<\/jats:sub>S and NO generation from ZYZ\u2010803 cooperatively regulated vascular tone through cGMP pathway, which indicated that ZYZ\u2010803 had therapeutic potential in cardiovascular diseases.<\/jats:p>","DOI":"10.1155\/2016\/7075682","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T21:04:01Z","timestamp":1447103041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Vasorelaxant Effect of a New Hydrogen Sulfide\u2010Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway"],"prefix":"10.1155","volume":"2016","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingxun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenfen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Zhun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.6.1298"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0786-4"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.11.006"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.081"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0608-z"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.12.023"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.10.007"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.002"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202916109"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.154"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706906"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016112798829823"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm960379t"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2956"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2947"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(02)00504-7"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00331.2004"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191221183"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn140"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.87.9.825"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00013.2002"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/804659"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.001631"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5381"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.12.005"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053319"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12475"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6255com"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2279fje"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.87.11.999"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.209783"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/7075682.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/7075682.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/7075682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:25:41Z","timestamp":1722907541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/7075682"}},"subtitle":[],"editor":[{"given":"Jin-Song","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,11,9]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/7075682"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7075682","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,9]]},"assertion":[{"value":"2015-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7075682"}}