{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:34:58Z","timestamp":1776987298343,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cScientific Research Projects Coordination Unit\u201d of Istanbul University","award":["55673"],"award-info":[{"award-number":["55673"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Endocan has been shown to be a marker for several cancers and may show degree of malignancy. The aim of this study is to assess tissue levels of endocan in common brain tumors, namely, meningiomas, low-grade gliomas (LGGs), and high-grade gliomas (HGGs).<jats:italic>Patients and Methods<\/jats:italic>. Endocan was assayed by commercially available enzyme linked immunosorbent assay (ELISA) kits in a total of 50 brain tumors (20 meningiomas, 19 LGGs, and 20 HGGs) and 15 controls. The results were compared to control brain tissues.<jats:italic>Results<\/jats:italic>. Each tumor group showed significant higher levels of endocan compared to controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). In addition, endocan levels showed steady increase from the least (meningiomas) to the most (HGGs) malignant tumors and positive correlation was noted between the degree of malignancy and endocan level (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0001<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Endocan, a vital molecule for angiogenesis, is expressed in common brain tumors and results suggest that endocan could be a marker for malignancy.<\/jats:p>","DOI":"10.1155\/2016\/7157039","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T20:41:52Z","timestamp":1469652112000},"page":"1-5","source":"Crossref","is-referenced-by-count":13,"title":["Expressions of Endocan in Patients with Meningiomas and Gliomas"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-4205","authenticated-orcid":true,"given":"Pinar","family":"Atukeren","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2209-8187","authenticated-orcid":true,"given":"Ahmad","family":"Kunbaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, 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Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nursel","family":"Turkmen Inanir","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Uludag University, Bursa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1878-0696","authenticated-orcid":true,"given":"Taner","family":"Tanriverdi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Fatih, 34098 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20458"},{"issue":"18","key":"3","first-page":"6084","volume":"63","year":"2003","journal-title":"Cancer 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