{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:49:17Z","timestamp":1791377357314,"version":"4.3.2"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RGP-1435-093"],"award-info":[{"award-number":["RGP-1435-093"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    The present study aimed to examine the protective role of\n                    <jats:italic>Spirulina platensis<\/jats:italic>\n                    (\n                    <jats:italic>S. platensis<\/jats:italic>\n                    ) against arsenic\u2010induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO\n                    <jats:sub>2<\/jats:sub>\n                    at a dose of 6.3\u2009mg\/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc. Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T\n                    <jats:sub>3<\/jats:sub>\n                    ), and thyroxine (T\n                    <jats:sub>4<\/jats:sub>\n                    ) levels and reduced sperm motility and sperm count. Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), nitric oxide (NO), and sperm abnormalities.\n                    <jats:italic>S. platensis<\/jats:italic>\n                    at a dose of 300\u2009mg\/kg was found to attenuate As\u2010induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity.\n                    <jats:italic>S. platensis<\/jats:italic>\n                    may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.\n                  <\/jats:p>","DOI":"10.1155\/2016\/7174351","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T02:09:01Z","timestamp":1452737341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Antioxidant Potential of\n                    <i>Spirulina platensis<\/i>\n                    Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Samir A. E.","family":"Bashandy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"El Awdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"Ebaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"Alhazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,13]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4274(02)00086-3"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.245"},{"key":"e_1_2_7_3_2","first-page":"27","article-title":"Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats","volume":"5","author":"Sarkar M.","year":"2003","journal-title":"Asian Journal of Andrology"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht467oa"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.11.009"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.03.001"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.12.003"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557511313080009"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-103"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2010.00200.x"},{"key":"e_1_2_7_11_2","first-page":"235","article-title":"The study of biochemical and histopathological effects of spirulina in rats with TNBS-induced colitis","volume":"112","author":"Coskun Z. K.","year":"2011","journal-title":"Bratislava Medical Journal"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5.377"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1783"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nen058"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050256"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5195"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(00)00193-3"},{"key":"e_1_2_7_18_2","first-page":"371","article-title":"Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat","volume":"45","author":"Rana S. V. S.","year":"2007","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_7_19_2","first-page":"589","article-title":"Interaction of Pb(II) ions with C-phycocyanin from Spirulina platensis: effect of ionic strength","volume":"48","author":"Gelagutashvili E. S.","year":"2003","journal-title":"Biofizika"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059177"},{"key":"e_1_2_7_21_2","volume-title":"Dangerous Properties of Industrial Materials","author":"Lewis R.","year":"1996"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2008.09.041"},{"key":"e_1_2_7_23_2","first-page":"81","article-title":"A scientific review of age determination for a laboratory rat: how old is it in comparison with human age?","volume":"2","author":"Sengupta P.","year":"2011","journal-title":"Biomedicine International"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2005.08.012"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-4652(199811)177:2<324::aid-jcp14>3.0.co;2-9"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.12720\/jomb.3.3.149-153"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3287616"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(00)00046-6"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83842-5"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx9901231"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx990115k"},{"key":"e_1_2_7_32_2","first-page":"45","article-title":"Microalgae Spirulina in human nutrition","volume":"73","author":"Mazo V. K.","year":"2004","journal-title":"Voprosy Pitaniia"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.6000\/1927-5951.2011.01.02.04"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.11.2395"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16021055"},{"key":"e_1_2_7_36_2","first-page":"177","article-title":"Effect of vitamin E supplementation on diabetes induced oxidative stress in experimental diabetes in rats","volume":"43","author":"Garg M. C.","year":"2005","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1081\/pfc-100104191"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2013.04.002"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.5.L1057"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000055318.09997.1f"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-210-43927aa"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.12.5337"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.24.7.2593-2604.2004"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.01.018"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-003-0365-9"},{"key":"e_1_2_7_46_2","first-page":"155","article-title":"The effect of thyroid activity on adult rat spermatogenesis","volume":"8","author":"Ai J.","year":"2007","journal-title":"Iranian Journal of Veterinary Research, University of Shiraz"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod62.3.664"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1071\/rd9950659"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.069"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.05.074"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.02.016"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.007"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4320(02)00226-9"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327108102046"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/7174351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/7174351.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/7174351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T21:47:11Z","timestamp":1722894431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/7174351"}},"subtitle":[],"editor":[{"given":"Ilaria","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/7174351"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7174351","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7174351"}}