{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:16:16Z","timestamp":1749096976382,"version":"3.41.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. We report a case of bilateral posterior subcapsular cataracts (PSCs) in a 24-year-old man with an allergic conjunctivitis history caused by a long-term therapy with glucocorticoids.<jats:italic>Case Presentation<\/jats:italic>. The patient showed a visual acuity of 9\/10 for both eyes. He followed a therapy with ketotifen and bilastine for four years. During the last six months before our evaluation, he was treated with chloramphenicol and betamethasone, interrupted for onset of cataracts and increased intraocular pressure. We treated him with ophthalmic gel preparation containing a new recombinant form of manganese superoxide dismutase (rMnSOD) at a concentration of 12.5\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, only for the right eye, while left eye was treated with standard protocol of Bendazac-lysine g 0.5.<jats:italic>Conclusion<\/jats:italic>. This case report shows the protective effects of rMnSOD versus PSC disease, probably due to the capacity of rMnSOD of countering free radical species.<\/jats:p>","DOI":"10.1155\/2016\/7240209","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T21:03:09Z","timestamp":1471467789000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["A Gel Formulation Containing a New Recombinant Form of Manganese Superoxide Dismutase: A Clinical Experience Based on Compassionate Use-Safety of a Case Report"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-1819","authenticated-orcid":true,"given":"Lucia","family":"Grumetto","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Del","family":"Prete","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive and Dentistry Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Ortosecco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Molecular Biology and Viral Oncology Unit, Department of Experimental Oncology, National Institute of Cancer, IRCCS Foundation, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore Del","family":"Prete","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive and Dentistry Sciences, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Mancini","sequence":"additional","affiliation":[{"name":"Leadhexa Inc., QB3-UCSF, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(99)80239-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(92)31934-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.2.165"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5193"},{"key":"5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1089\/jop.2006.0067","volume":"23","year":"2007","journal-title":"Journal of Ocular Pharmacology and Therapeutics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01583.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/38143"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/15672018113106660062"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.09.013"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000265520"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/973197"},{"issue":"5","key":"12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1755-3768.1994.tb07192.x","volume":"72","year":"1994","journal-title":"Acta Ophthalmologica"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21904"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/srep18691"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199039040-00007"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/7240209.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/7240209.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2016\/7240209.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T18:57:20Z","timestamp":1749063440000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2016\/7240209\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"alternative-id":["7240209","7240209"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7240209","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2016]]}}}