{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:24:26Z","timestamp":1772965466820,"version":"3.50.1"},"reference-count":46,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. An epidemiological association between exposure to phthalates and type 2 diabetes (T2D) is known. However, the potential role of environmental phthalates in the complications of T2D is unknown.<jats:italic>Methods<\/jats:italic>. Using data from the National Health and Nutrition Examination Survey (NHANES) 2001\u20132010, we studied the association of 12 urinary phthalate metabolites with self-reported eye affliction\/retinopathy in 1,004 participants with diabetes. Data from retinal imaging was used to validate this outcome. Independence of the phthalates<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u2192<\/mml:mi><\/mml:mrow><\/mml:math>T2D association was studied by adjusting for age, sex, race, marital status, educational attainment, poverty income ratio, physical activity, glycated hemoglobin levels, total serum cholesterol, serum high-density lipoprotein cholesterol, serum triglycerides, blood pressure, duration of diabetes, total calorie intake, and obesity.<jats:italic>Results<\/jats:italic>. Self-reported eye affliction\/retinopathy had 82% accuracy with Cohen\u2019s kappa of 0.31 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Urinary mono-n-octyl phthalate (MOP) was independently associated with the likelihood of self-reported eye affliction\/retinopathy in subjects with T2D after accounting for all the confounders. This significance of this association was robust to the potential misclassification in cases and controls of retinopathy. Further, a significant dose-response relationship between MOP and self-reported eye affliction\/retinopathy was demonstrable.<jats:italic>Conclusions<\/jats:italic>. We show a novel epidemiological link between the environment and diabetic complications in NHANES 2001\u20132010 participants.<\/jats:p>","DOI":"10.1155\/2016\/7269896","type":"journal-article","created":{"date-parts":[[2015,12,20]],"date-time":"2015-12-20T16:01:04Z","timestamp":1450627264000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Association of Urinary Phthalates with Self-Reported Eye Affliction\/Retinopathy in Individuals with Diabetes: National Health and Nutrition Examination Survey, 2001\u20132010"],"prefix":"10.1155","volume":"2016","author":[{"given":"Manju","family":"Mamtani","sequence":"first","affiliation":[{"name":"South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne E.","family":"Curran","sequence":"additional","affiliation":[{"name":"South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Blangero","sequence":"additional","affiliation":[{"name":"South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemant","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2396"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2011.05.015"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069x-13-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-4022"},{"issue":"9","key":"5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1289\/ehp.1104717","volume":"120","year":"2012","journal-title":"Environmental Health Perspectives"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9882"},{"issue":"4","key":"7","first-page":"139","volume":"119","year":"2004","journal-title":"The Indian Journal of Medical Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00233.2011"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.01035.x"},{"issue":"3","key":"10","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jcb.24399","volume":"114","year":"2013","journal-title":"Journal of Cellular Biochemistry"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.05.020"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2011.12.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-009-0627-8"},{"issue":"4","key":"14","first-page":"231","volume":"36","year":"2006","journal-title":"Turkish Journal of Medical Sciences"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1231"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.08.045"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1111"},{"issue":"5, supplement","key":"18","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0161-6420(13)38014-2","volume":"98","year":"1991","journal-title":"Ophthalmology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.017590"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.02.038"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290054029"},{"key":"22","year":"2010"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(91)32145-6"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0306"},{"issue":"5","key":"25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1001\/jamaophthalmol.2014.5108","volume":"133","year":"2015","journal-title":"JAMA Ophthalmology"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0793"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0648"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0884-6"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.119637"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.002529"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0628"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1900\/rds.2011.9.6"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.11.006"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-007-9049-x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042750"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0398oc"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e3181e5c1f7"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1677\/joe-07-0198"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq015"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.11.004"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500x.92497"},{"key":"42","first-page":"1449","volume":"4","year":"2012","journal-title":"Frontiers in Bioscience"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.2174\/138920111794480615"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1021\/pr9006415"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7212"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1080\/15287390500227381"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2016\/7269896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2016\/7269896.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2016\/7269896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T22:10:14Z","timestamp":1498255814000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jdr\/2016\/7269896\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":46,"alternative-id":["7269896","7269896"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7269896","relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}