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Increases in red blood cell distribution width (RDW) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) predict the mortality of chronic heart failure patients undergoing cardiac resynchronization therapy (CRT). It was hypothesized that RDW is independent of and possibly even superior to NT-proBNP from the aspect of long-term mortality prediction.<jats:italic>Design<\/jats:italic>. The blood counts and serum NT-proBNP levels of 134 patients undergoing CRT were measured. Multivariable Cox regression models were applied and reclassification analyses were performed.<jats:italic>Results<\/jats:italic>. After separate adjustment to the basic model of left bundle branch block, beta blocker therapy, and serum creatinine, both the RDW &gt; 13.35% and NT-proBNP &gt; 1975\u2009pg\/mL predicted the 5-year mortality (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">57<\/mml:mn><\/mml:math>). In the final model including all variables, the RDW [HR = 2.49 (1.27\u20134.86);<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.008<\/mml:mn><\/mml:math>] remained a significant predictor, whereas the NT-proBNP [HR = 1.18 (0.93\u20133.51);<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.07<\/mml:mn><\/mml:math>] lost its predictive value. On addition of the RDW measurement, a 64% net reclassification improvement and a 3% integrated discrimination improvement were achieved over the NT-proBNP-adjusted basic model.<jats:italic>Conclusions<\/jats:italic>. Increased RDW levels accurately predict the long-term mortality of CRT patients independently of NT-proBNP. Reclassification analysis revealed that the RDW improves the risk stratification and could enhance the optimal patient selection for CRT.<\/jats:p>","DOI":"10.1155\/2016\/7304538","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T21:34:15Z","timestamp":1453239255000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["Measurement of the Red Blood Cell Distribution Width Improves the Risk Prediction in Cardiac Resynchronization Therapy"],"prefix":"10.1155","volume":"2016","author":[{"given":"Andr\u00e1s Mih\u00e1ly","family":"Boros","sequence":"first","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor Utca 68, Budapest 1122, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Perge","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor Utca 68, Budapest 1122, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsigmond","family":"Jenei","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia","family":"Kar\u00e1dy","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor Utca 68, Budapest 1122, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endre","family":"Zima","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor Utca 68, Budapest 1122, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, V\u00e1rosmajor Utca 68, Budapest 1122, 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