{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:20:53Z","timestamp":1787509253241,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2016]]},"abstract":"\n We report data regarding kinetic of response to oral iron in 34 iron deficiency anemia children. Twenty-four\/34 patients (70.5%) reached reference value of hemoglobin (Hb) concentration for age and sex at day + 30 from the beginning of treatment (complete early responders (CERs)), and 4\/34 (12%) reached an Hb concentration at least 50% higher than the original (partial early responders (PERs)). CHr at T1 (within 7 days from the beginning of treatment) was significantly different in the different groups (22.95 in CERs versus 18.41 in other patients;\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ; 22.42 in early responders versus 18.07 in NERs;\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ). Relative increase of CHr from T0 to T1 resulted significantly higher in CERs than in other patients (0.21 versus 0.11,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.042<\/mml:mn>\n <\/mml:math>\n ) and in early responders than in NERs (0.22 versus 0.004,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.006<\/mml:mn>\n <\/mml:math>\n ). Multivariate logistic models revealed a higher probability of being a complete early responder due to relative increase of ARC from T0 to T1 [OR (95% CI) = 44.95 (1.54\u20131311.98)] and to CHr at T1 [OR (95% CI) =3.18 (1.24\u20138.17)]. Our preliminary data confirm CHr as early and accurate predictor of hematological response to oral iron.\n <\/jats:p>","DOI":"10.1155\/2016\/7345835","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T17:01:20Z","timestamp":1458666080000},"page":"1-6","source":"Crossref","is-referenced-by-count":25,"title":["Absolute Reticulocyte Count and Reticulocyte Hemoglobin Content as Predictors of Early Response to Exclusive Oral Iron in Children with Iron Deficiency Anemia"],"prefix":"10.1155","volume":"2016","author":[{"given":"Emilia","family":"Parodi","sequence":"first","affiliation":[{"name":"Pediatric and Neonatology Unit, Ordine Mauriziano Hospital, Largo Turati 62, 10128 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Giraudo","sequence":"additional","affiliation":[{"name":"Department of Mathematics \u201cG. Peano\u201d, University of Turin, Via Carlo Alberto 10, 10123 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Ricceri","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology, Regional Health Service ASL TO3, Via Sabaudia 164, Grugliasco, 10095 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luigia","family":"Aurucci","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Sciences of Public Health and Pediatrics, University of Turin, Piazza Polonia 94, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaela","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Hematology and Coagulation Laboratory, Citt\u00e0 della Scienza e della Salute Hospital, Piazza Polonia 94, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Ramenghi","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Sciences of Public Health and Pediatrics, University of Turin, Piazza Polonia 94, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2014.10.004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.23.2225"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.8.924"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0097-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21090"},{"issue":"10","key":"6","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1182\/blood.V83.10.3100.3100","volume":"83","year":"1994","journal-title":"Blood"},{"issue":"5","key":"7","first-page":"329","volume":"37","year":"2008","journal-title":"Pediatric Annals"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006465"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/mph.0b013e3182588996"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1457-5"}],"container-title":["Anemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2016\/7345835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2016\/7345835.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2016\/7345835.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T12:47:56Z","timestamp":1600346876000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/anemia\/2016\/7345835\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":10,"alternative-id":["7345835","7345835"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7345835","relation":{},"ISSN":["2090-1267","2090-1275"],"issn-type":[{"value":"2090-1267","type":"print"},{"value":"2090-1275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}