{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:39:23Z","timestamp":1790771963915,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270202"],"award-info":[{"award-number":["81270202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91339113"],"award-info":[{"award-number":["91339113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI103618"],"award-info":[{"award-number":["AI103618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Ischemia\/reperfusion (I\/R) injury induces irreversible oxidative stress damage to the cardiac muscle. We previously observed that CD38 deficiency remarkably protects mouse embryonic fibroblasts (MEFs) from oxidative stress\u2010induced injury. However, whether CD38 deficiency protects from I\/R injury in the heart is not explored. Here, we showed that the hearts of CD38 deficient mice or wild type mice supplied with exogenous NAD were significantly protected from ischemia\/reperfusion injury, seen as reduction of the myocardial infarct sizes when the mice were subjected to 30\u2009min ischemia followed by 24 hours of reperfusion. Consistently, the protection of CD38 deficiency on hypoxia\/reoxygenation (H\/R) injury was confirmed with a CD38 knockdown H9c2 stable cell line. Furthermore, we observed that knockdown of CD38 remarkably inhibited ROS generation and intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overloading induced by H\/R in H9c2 cells. The FOXO1 and FOXO3 expressions were significantly elevated by H\/R injury in CD38 knockdown cells compared with normal H9c2 cells. The cell immunofluorescence assay showed that FOXO1 nuclear translocation was significantly increased in CD38 knockdown H9c2 cells. In addition, we demonstrated that the increase of FOXO1 nuclear translocation was associated with the increased expressions of antioxidant catalase and SOD2 and the attenuated expression of the ROS generation enzyme NOX4. In conclusion, our results provide new evidence that CD38 deficiency protects the heart from I\/R injury through activating SIRT1\/FOXOs\u2010mediated antioxidative stress pathway.\n                  <\/jats:p>","DOI":"10.1155\/2016\/7410257","type":"journal-article","created":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T17:01:43Z","timestamp":1469984503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["CD38 Deficiency Protects the Heart from Ischemia\/Reperfusion Injury through Activating SIRT1\/FOXOs\u2010Mediated Antioxidative Stress 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