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However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress\u2010 (CUMS\u2010) induced depression in rats. Male SD rats were exposed to a CUMS\u2010inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test. Moreover, the expression of brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP\u2010response element binding protein (CREB) and extracellular signal\u2010regulated protein kinase (ERK 1\/2) were markedly decreased in the hippocampus in depressed rats. However, chronically treating the depressed rats with AS (1\u2009g\/kg) normalized their depression\u2010related behaviors and molecular profiles. In conclusion, in the present study, we show that AS extracts exerted antidepressant effects that were mediated by the BDNF signaling pathway: in AS\u2010treated depressed rats, the expression of the BDNF protein and the phosphorylation of its downstream targets (ERK 1\/2, CREB) were upregulated in the hippocampus.<\/jats:p>","DOI":"10.1155\/2016\/7434692","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T21:12:19Z","timestamp":1472159539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The Antidepressant Effect of <i>Angelica sinensis<\/i> Extracts on Chronic Unpredictable Mild Stress\u2010Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-4564","authenticated-orcid":false,"given":"Jun","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-5137","authenticated-orcid":false,"given":"Junjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1497-9964","authenticated-orcid":false,"given":"Min","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-5887","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-7799","authenticated-orcid":false,"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-2298","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.06.002"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.10.015"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.09.010"},{"key":"e_1_2_8_4_2","first-page":"16","article-title":"Real-world data on SSRI antidepressant side effects","volume":"6","author":"Cascade E.","year":"2009","journal-title":"Psychiatry"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/11595900-000000000-00000"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002075"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.03.006"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/309262"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/469765"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.5717\/jenb.2015.19.1.11"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.04.053"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.67"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.10.023"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.06.013"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.05.005"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291709005248"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/s1461145712000016"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-6-32"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-011-9202-8"},{"key":"e_1_2_8_20_2","first-page":"776","article-title":"Advances in the pharmacological studies of radix Angelica sinensis (oliv) Diels (Chinese Danggui)","volume":"104","author":"Mei Q. 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