{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:10:25Z","timestamp":1790838625792,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Meiji Co., Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Some<jats:italic>Lactobacillus<\/jats:italic>spp. suppress<jats:italic>Helicobacter pylori<\/jats:italic>in the stomach and have potential therapeutic applications for the treatment of gastrointestinal conditions. In this study, the effects of<jats:italic>Lactobacillus<\/jats:italic>strains on functional dyspepsia associated with<jats:italic>H. pylori<\/jats:italic>infection were examined. Volunteers were screened using the<jats:sup>13<\/jats:sup>C-urea breath test (UBT) and<jats:italic>H. pylori<\/jats:italic>stool test, and 131 participants who met the selection criteria (mean age: 48.9 years) were randomly given<jats:italic>L. gasseri<\/jats:italic>OLL2716-containing yogurt or placebo yogurt once daily for 12 weeks. Gastrointestinal symptoms (epigastric pain, bloating, postprandial fullness, nausea, and heartburn) and the levels of serum pepsinogen (PG),<jats:sup>13<\/jats:sup>C-UBT, and<jats:italic>H. pylori<\/jats:italic>stool antigen were assessed. No significant differences were observed between the groups in UBT results,<jats:italic>H. pylori<\/jats:italic>stool antigens, or the serum PGI\/II ratio. In the<jats:italic>L. gasseri<\/jats:italic>group, postprandial fullness was significantly lower at the end of the trial compared to the initial level (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) and significantly fewer patients had a VAS score of &gt;10 for bloating compared to the placebo group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Dietary supplementation with<jats:italic>L. gasseri<\/jats:italic>OLL2716-containing yogurt may effectively suppress dyspeptic symptoms in<jats:italic>H. pylori<\/jats:italic>-infected patients. This study was registered at the University Hospital Medical Network Clinical Trial Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr\/ctr.cgi?function=brows&amp;action=brows&amp;type=summary&amp;recptno=R000019422&amp;language=E\">UMIN000016746<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2016\/7490452","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T18:27:25Z","timestamp":1468261645000},"page":"1-6","source":"Crossref","is-referenced-by-count":41,"title":["Effects of<i>Lactobacillus gasseri<\/i>OLL2716 on<i>Helicobacter pylori<\/i>-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0067-4008","authenticated-orcid":true,"given":"Atsushi","family":"Takagi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-0840","authenticated-orcid":true,"given":"Hidetaka","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa 259-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba 272-8516, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-0985","authenticated-orcid":true,"given":"Shigemi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Social Insurance Shiga Hospital, 16-1 Fujimidai, Otsu, Shiga 520-0846, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Tokyo Medical College, 6-7-1 Nishishijuku, Tokyo 160-0023, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Ohtsu","sequence":"additional","affiliation":[{"name":"Research & Development Laboratories, Meiji Co. 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