{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:05:14Z","timestamp":1763705114431,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catalan Diabetes Association"},{"name":"Boehringer-Ingelheim"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. To assess prescribing practices of noninsulin antidiabetic drugs (NIADs) in T2DM with several major contraindications according to prescribing information or clinical guidelines: renal failure, heart failure, liver dysfunction, or history of bladder cancer.<jats:italic>Methods<\/jats:italic>. Cross-sectional, descriptive, multicenter study. Electronic medical records were retrieved from all T2DM subjects who attended primary care centers pertaining to the Catalan Health Institute in Catalonia in 2013 and were pharmacologically treated with any NIAD alone or in combination.<jats:italic>Results<\/jats:italic>. Records were retrieved from a total of 255,499 pharmacologically treated patients. 78% of patients with some degree of renal impairment (glomerular filtration rate (GFR) &lt; 60\u2009mL\/min) were treated with metformin and 31.2% with sulfonylureas. Even in the event of severe renal failure (GFR &lt; 30\u2009mL\/min), 35.3% and 22.5% of patients were on metformin or sulfonylureas, respectively. Moreover, metformin was prescribed to more than 60% of patients with moderate or severe heart failure.<jats:italic>Conclusion<\/jats:italic>. Some NIADs, and in particular metformin, were frequently used in patients at high risk of complications when they were contraindicated. There is a need to increase awareness of potential inappropriate prescribing and to monitor the quality of prescribing patterns in order to help physicians and policymakers to yield better clinical outcomes in T2DM.<\/jats:p>","DOI":"10.1155\/2016\/7502489","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T16:04:28Z","timestamp":1452096268000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications?"],"prefix":"10.1155","volume":"2016","author":[{"given":"Irene","family":"Ruiz-Tamayo","sequence":"first","affiliation":[{"name":"Primary Health Care Center La Torrassa, Consorci Sanitari Integral, Ronda Torrassa 151-153, 08903 L\u2019Hospitalet de Llobregat, Spain"},{"name":"DAP-Cat Group, Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Sardenya 375, 08006 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Franch-Nadal","sequence":"additional","affiliation":[{"name":"DAP-Cat Group, Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Sardenya 375, 08006 Barcelona, Spain"},{"name":"Primary Health Care Center Raval Sud, Ger\u00e8ncia d\u2019\u00c0mbit d\u2019Atenci\u00f3 Prim\u00e0ria Barcelona Ciutat, Institut Catal\u00e0 de la Salut, Avinguda Drassanes 17-21, 08001 Barcelona, Spain"},{"name":"CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Monforte de Lemos 3-5, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Mata-Cases","sequence":"additional","affiliation":[{"name":"DAP-Cat Group, Unitat de Suport a la Recerca Barcelona Ciutat, Institut 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