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Persistent<jats:italic>Helicobacter pylori<\/jats:italic>infection may induce several upper gastrointestinal diseases. Two major virulence factors of<jats:italic>H. pylori<\/jats:italic>, vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), are thought to be associated with the severity of disease progression. The distribution of<jats:italic>vacA<\/jats:italic>and<jats:italic>cag<\/jats:italic>-pathogenicity island (<jats:italic>cag<\/jats:italic>-PAI) alleles varies in<jats:italic>H. pylori<\/jats:italic>isolated from patients in different geographic regions.<jats:italic>Aim<\/jats:italic>. To assess the association between mixed infection of<jats:italic>H. pylori<\/jats:italic>clinical isolates from Taiwanese patients and the severity of gastrointestinal diseases.<jats:italic>Methods<\/jats:italic>. A total of 70 patients were enrolled in this study. Six distinct and well-separated colonies were isolated from each patient and 420 colonies were analyzed to determine the genotypes of virulence genes.<jats:italic>Results<\/jats:italic>. The prevalence of mixed infections of all<jats:italic>H. pylori<\/jats:italic>-infected patients was 28.6% (20\/70). The rate of mixed infections in patients with duodenal ulcer (47.6%) was much higher than that with other gastrointestinal diseases (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>.<jats:italic>H. pylori<\/jats:italic>mixed infections show high genetic diversity that may enhance bacterial adaptation to the hostile environment of the stomach and contribute to disease development.<\/jats:p>","DOI":"10.1155\/2016\/7521913","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T21:04:21Z","timestamp":1474578261000},"page":"1-5","source":"Crossref","is-referenced-by-count":15,"title":["Mixed Infections of<i>Helicobacter pylori<\/i>Isolated from Patients with Gastrointestinal Diseases in 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