{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:04:55Z","timestamp":1790928295033,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>\n                    <jats:italic>Background and Objectives<\/jats:italic>\n                    . Nailfold capillaroscopy is an easy and noninvasive technique used to investigate dermal microvasculature. Traditional investigations of vascularity do not detect changes until they are well-established in type 2 diabetics. The objective of the current study was to evaluate nailfold capillaries in type 2 diabetes mellitus patients and to determine the association of retinopathy with changes in the nailfold capillaries.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . Capillaroscopic findings by nailfold capillaroscopy and fundoscopic examinations were assessed in 216 patients with type 2 diabetes mellitus and 101 healthy controls included in this prospective study.\n                    <jats:italic>Results<\/jats:italic>\n                    . Retinopathy was detected in 43.05% of diabetic patients (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>n<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">93<\/mml:mn>\n                    <\/mml:math>\n                    ). Capillaroscopic findings including tortuosity (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), bushy capillary (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), neoformation (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), bizarre capillary (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), microhemorrhage (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.001<\/mml:mn>\n                    <\/mml:math>\n                    ), capillary ectasia (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.002<\/mml:mn>\n                    <\/mml:math>\n                    ), and aneurysm (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.004<\/mml:mn>\n                    <\/mml:math>\n                    ) were significantly higher in diabetic group than control group. In logistic regression analysis, only tortuosity was shown significant (OR, 2.16;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn fontstyle=\"italic\">0.036<\/mml:mn>\n                    <\/mml:math>\n                    ). There was also a significant relation between diabetes duration and most of the capillaroscopic findings.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Capillaroscopic changes were found to be correlated with diabetic retinopathy, in particular with longer disease duration in our study. Capillaroscopic imaging could be a useful new technique for assessment of diabetic microvascular changes.\n                  <\/jats:p>","DOI":"10.1155\/2016\/7592402","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T16:03:50Z","timestamp":1481645030000},"page":"1-7","source":"Crossref","is-referenced-by-count":46,"title":["Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-8248","authenticated-orcid":true,"given":"Seyit","family":"Uyar","sequence":"first","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Balkarl\u0131","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Rheumatology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-8065","authenticated-orcid":true,"given":"Muhammet Kaz\u0131m","family":"Erol","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayram","family":"Ye\u015fil","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Toku\u00e7","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u011fan","family":"Durmaz","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcheyla","family":"G\u00f6rar","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Endocrinology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan Hilmi","family":"\u00c7ekin","sequence":"additional","affiliation":[{"name":"University of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"S1","volume":"38","year":"2015","journal-title":"Diabetes Care"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1379274"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/854593"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.114.303090"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/974530"},{"key":"6","first-page":"331","volume-title":"Nailfold capillaroscopy","year":"2012"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.8.1027"},{"key":"8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.berh.2013.03.001","volume":"27","year":"2013","journal-title":"Best Practice & Research Clinical 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