{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:47:14Z","timestamp":1787946434729,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["DEC-2011\/03\/B\/NZ5\/04192"],"award-info":[{"award-number":["DEC-2011\/03\/B\/NZ5\/04192"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic> In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA).<jats:italic> Patients and Methods.<\/jats:italic> We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF).<jats:italic> Results.<\/jats:italic> Patients with acute anterior uveitis (AAU) had higher VAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0008<\/mml:mn><\/mml:math>), BADSDAI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0001<\/mml:mn><\/mml:math>), ASDAS-ESR (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>), CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.006<\/mml:mn><\/mml:math>), IL-6 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>), and IL-18 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.03<\/mml:mn><\/mml:math>) levels. Patients with inflammatory bowel disease (IBD) had higher VAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.03<\/mml:mn><\/mml:math>), CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0009<\/mml:mn><\/mml:math>), and IL-6 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0003<\/mml:mn><\/mml:math>) levels. Patients with skin psoriasis had lower VAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and BASDAI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.00007<\/mml:mn><\/mml:math>) levels. Patients with psoriatic onycholysis had lower VAS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.006<\/mml:mn><\/mml:math>), BASDAI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.00001<\/mml:mn><\/mml:math>), and CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.02<\/mml:mn><\/mml:math>) and higher IL-23 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>) levels. Patients with PPP had lower BASDAI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.04<\/mml:mn><\/mml:math>) and higher ET-1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) levels.<jats:italic> Conclusions.<\/jats:italic> SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.<\/jats:p>","DOI":"10.1155\/2016\/7617954","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T21:01:27Z","timestamp":1481144487000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-2594","authenticated-orcid":true,"given":"Hanna","family":"Przepiera-B\u0119dzak","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Fischer","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Brzosko","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"3","first-page":"333","volume-title":"The SAPHO-syndrome","volume":"8","year":"1994"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu388"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0627-0"},{"issue":"3","key":"6","first-page":"319","volume":"8","year":"2015","journal-title":"Journal of Medicine and Life"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2652-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203582"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2014.04.003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.10.927"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-1011-0"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken185"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081255"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/785705"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02101.x"},{"issue":"6","key":"16","first-page":"297","volume":"123","year":"2013","journal-title":"Polskie Archiwum Medycyny Wewnetrznej"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.3341"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2016.1158283"},{"issue":"5","key":"19","first-page":"284","volume":"7","year":"2010","journal-title":"International Journal of Medical Sciences"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i3.1067"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02963.x"},{"issue":"12","key":"22","first-page":"2286","volume":"21","year":"1994","journal-title":"Journal of Rheumatology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701523147"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0007-2"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/7617954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/7617954.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2016\/7617954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T11:08:02Z","timestamp":1589713682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2016\/7617954\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"alternative-id":["7617954","7617954"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7617954","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}