{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:01:52Z","timestamp":1789664512237,"version":"4.0.1"},"reference-count":45,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The importance of personalized medicine and healthcare is becoming increasingly recognized. Genetic polymorphisms associated with potential risks of various human genetic diseases as well as drug-induced adverse reactions have recently been well studied, and their underlying molecular mechanisms are being uncovered by functional genomics as well as genome-wide association studies. Knowledge of certain genetic polymorphisms is clinically important for our understanding of interindividual differences in drug response and\/or disease risk. As such evidence accumulates, new clinical applications and practices are needed. In this context, the development of new technologies for simple, fast, accurate, and cost-effective genotyping is imperative. Here, we describe a simple isothermal genotyping method capable of detecting single nucleotide polymorphisms (SNPs) in the human ATP-binding cassette (ABC) transporter<jats:italic>ABCC11<\/jats:italic>gene and its application to the clinical diagnosis of axillary osmidrosis. We have recently reported that axillary osmidrosis is linked with one SNP 538G&gt;A in the<jats:italic>ABCC11<\/jats:italic>gene. Our molecular biological and biochemical studies have revealed that this SNP greatly affects the protein expression level and the function of ABCC11. In this review, we highlight the clinical relevance and importance of this diagnostic strategy in axillary osmidrosis therapy.<\/jats:p>","DOI":"10.1155\/2016\/7670483","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T16:02:33Z","timestamp":1456243353000},"page":"1-9","source":"Crossref","is-referenced-by-count":28,"title":["Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human<i>ABCC11<\/i>Gene: Clinical Practice and Basic Scientific Evidence"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yu","family":"Toyoda","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneaki","family":"Gomi","sequence":"additional","affiliation":[{"name":"Gomi Clinic, 1-10-12 Hyakunin-cho, Shinjyuku-ku, Tokyo 169-0073, 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