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The replication-deficient, human adenovirus-vectored FMD vaccine has been proven effective against FMD. However, the role of T-cell-mediated antiviral responses and the mucosae-mediated antiviral responses induced by the adenovirus-vectored FMD vaccine was rarely examined. Here, the capsid protein precursor P1-2A and viral protease 3C of the type O FMDV were expressed in replicative-deficient human adenovirus type 5 vector. BALB\/c mice immunized intramuscularly and intraperitoneally with recombinant adenovirus rAdv-P12A3C elicited higher FMDV-specific IgG antibodies, IFN-<jats:italic>\u03b3<\/jats:italic>, and IL-4 cytokines than those in mice immunized with inactivated FMDV vaccine. Moreover, BALB\/c mice immunized with recombinant adenovirus rAdv-P12A3C by oral and intraocular-nasal immunization induced high FMDV-specific IgA antibodies. These results show that the recombinant adenovirus rAdv-P12A3C could resist FMDV comprehensively. This study highlights the potential of rAdv-P12A3C to serve as a type O FMDV vaccine.<\/jats:p>","DOI":"10.1155\/2016\/7849203","type":"journal-article","created":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T21:00:30Z","timestamp":1468184430000},"page":"1-9","source":"Crossref","is-referenced-by-count":9,"title":["A Recombinant Adenovirus Expressing P12A and 3C Protein of the Type O Foot-and-Mouth Disease Virus Stimulates Systemic and Mucosal Immune Responses in Mice"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-7165","authenticated-orcid":true,"given":"Yinli","family":"Xie","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Grazing Animal Diseases of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"},{"name":"College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Grazing Animal Diseases of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-9571","authenticated-orcid":true,"given":"Zhiyong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Grazing Animal Diseases of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268814003033"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve122"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268814003033"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00261-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.08.039"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-3-671"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9940"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00384-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.045732-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83417-0"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9717"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268896007376"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02245-10"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(90)90005-Z"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2005.08.009"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.02.028"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.09.011"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00483-2"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1128\/JVI.66.4.1835-1840.1992","volume":"66","year":"1992","journal-title":"Journal of Virology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-9571(03)00018-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.14.2.430-445.2001"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.05.001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/7849203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/7849203.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/7849203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T18:52:53Z","timestamp":1600887173000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/7849203\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"alternative-id":["7849203","7849203"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7849203","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}