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In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics. Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects. Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia. In this sense, green tea catechins seem to be a promising alternative because of the significant effect of Epigallocatechin-3-Gallate (E3G) on the electrocardiographic wave forms of guinea pig hearts. Thus, the aim of this study was to evaluate the benefits-risks balance of E3G consumption in the setting of ion channel mutations linked with aberrant cardiac excitability phenotypes. Two gain-of-function mutations,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>Na<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>v<\/mml:mtext><mml:mn fontstyle=\"italic\">1.5<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>-p.R222Q and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>Na<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>v<\/mml:mtext><mml:mn fontstyle=\"italic\">1.5<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>-p.I141V, which are linked with cardiac hyperexcitability phenotypes were studied. Computer simulations of action potentials (APs) show that 30\u2009<jats:italic>\u03bc<\/jats:italic>M E3G reduces and suppresses AP abnormalities characteristics of these phenotypes. These results suggest that E3G may have a beneficial effect in the setting of cardiac sodium channelopathies displaying a hyperexcitability phenotype.<\/jats:p>","DOI":"10.1155\/2016\/7861653","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T17:01:06Z","timestamp":1478106066000},"page":"1-17","source":"Crossref","is-referenced-by-count":5,"title":["<i>In Silico<\/i>Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies"],"prefix":"10.1155","volume":"2016","author":[{"given":"Maroua","family":"Boukhabza","sequence":"first","affiliation":[{"name":"Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah, Fez, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaouad","family":"El Hilaly","sequence":"additional","affiliation":[{"name":"Materials, Natural Substances, Environment and Modeling 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