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However, the curative mechanism has not been fully clarified. The study was designed to investigate the effect of TXYF on the colonic ion transport induced by serotonin (5\u2010HT) in D\u2010IBS rats. A method of multiple stress (neonatal maternal separation (NMS) combined with restraint stress (RS)) was used to induce the D\u2010IBS model. The model rats were randomly divided into two groups: NMS + RS group and TXYF\u2010formula group, and the normal control (no handling) rats were classified as NH group. In the NMS + RS group, the change of short\u2010circuit current (\u0394<jats:italic>I<\/jats:italic><jats:sub>sc<\/jats:sub>) induced by 5\u2010HT was lower than that in the NH and TXYF\u2010formula groups. After removing of the extracellular Cl<jats:sup>\u2212<\/jats:sup> or  or basolateral Na<jats:sup>+<\/jats:sup> or blocking the cystic fibrosis transmembrane conductance regulator (CFTR), Na<jats:sup>+<\/jats:sup>\u2010K<jats:sup>+<\/jats:sup>\u20102Cl<jats:sup>\u2212<\/jats:sup> cotransporter (NKCC),  cotransporter,  exchanger, K<jats:sup>+<\/jats:sup> channel, or Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase, respectively, there was no difference in 5\u2010HT\u2010induced \u0394<jats:italic>I<\/jats:italic><jats:sub>sc<\/jats:sub> among the three groups. These data suggest that TXYF can regulate 5\u2010HT\u2010induced Cl<jats:sup>\u2212<\/jats:sup> and  secretion, possibly mediated by the combined action of CFTR, NKCC, Na<jats:sup>+<\/jats:sup>\u2010 cotransporter,  exchanger, K<jats:sup>+<\/jats:sup> channel, and Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase.<\/jats:p>","DOI":"10.1155\/2016\/7954982","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T21:05:18Z","timestamp":1465938318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of TongXie\u2010YaoFang on Cl<sup>\u2212<\/sup> and HCO3\u2009- Transport in Diarrhea\u2010Predominant Irritable Bowel Syndrome Rats"],"prefix":"10.1155","volume":"2016","author":[{"given":"Xiaofang","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-1727","authenticated-orcid":false,"given":"Shengsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01001.x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06930.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i26.8103"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1101449"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709091003"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.10.020"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2012.04.002"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127815"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2016.1140571"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-009-0216-7"},{"key":"e_1_2_7_11_2","first-page":"56","article-title":"Clinical observation on Tong Xie Yao Fang pulsing for the treatment of 56 cases of diarrhea predominant irritable bowel syndrome","volume":"49","author":"Huang P.-R.","year":"2008","journal-title":"Journal of Traditional Chinese Medieine"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.663"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.031"},{"key":"e_1_2_7_14_2","first-page":"371","article-title":"Role of serotonin in the pathophysiology of the irritable bowel syndrome","volume":"60","author":"Moskwa A.","year":"2007","journal-title":"Wiadomo\u015bci Lekarskie"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2004.04015.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13216"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932863"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703414"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0243-3"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00314.2002"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00400.2006"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2014.29.2.169"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-9573.2006.00248.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-015-9757-y"},{"key":"e_1_2_7_25_2","volume-title":"Formulas of Chinese Medicine","author":"Deng Z. 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