{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:34:13Z","timestamp":1790390053207,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Macao Science and Technology Development","award":["052\/2013\/A2"],"award-info":[{"award-number":["052\/2013\/A2"]}]},{"name":"Macao Science and Technology Development","award":["2014JY0233"],"award-info":[{"award-number":["2014JY0233"]}]},{"name":"Basic Research for Application of Sichuan Province","award":["052\/2013\/A2"],"award-info":[{"award-number":["052\/2013\/A2"]}]},{"name":"Basic Research for Application of Sichuan Province","award":["2014JY0233"],"award-info":[{"award-number":["2014JY0233"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Erigeron multiradiatus<\/jats:italic>(Lindl.) Benth. has been used in Tibet folk medicine to treat various inflammatory diseases. The aim of this study was to investigate antimyocardial ischemia and reperfusion (I\/R) injury effect of caffeoylquinic acids derivatives of<jats:italic>E. multiradiatus<\/jats:italic>(AE)<jats:italic>in vivo<\/jats:italic>and to explain underling mechanism. AE was prepared using the whole plant of<jats:italic>E. multiradiatus<\/jats:italic>and contents of 6 caffeoylquinic acids determined through HPLC analysis. Myocardial I\/R was induced by left anterior descending coronary artery occlusion for 30 minutes followed by 24 hours of reperfusion in rats. AE administration (10, 20, and 40\u2009mg\/kg) inhibited I\/R-induced injury as indicated by decreasing myocardial infarct size, reducing of CK and LDH activities, and preventing ST-segment depression in dose-dependent manner. AE decreased cardiac tissue levels of proinflammatory factors TNF-<jats:italic>\u03b1<\/jats:italic>and IL-6 and attenuated leukocytes infiltration. AE was further demonstrated to significantly inhibit I-<jats:italic>\u03ba<\/jats:italic>B degradation, nuclear translocation of p-65 and phosphorylation of JNK. Our results suggested that cardioprotective effect of AE could be due to suppressing myocardial inflammatory response and blocking NF-<jats:italic>\u03ba<\/jats:italic>B and JNK activation pathway. Thus, caffeoylquinic acids might be the active compounds in<jats:italic>E. multiradiatus<\/jats:italic>on myocardial ischemia and be a potential natural drug for treating myocardial I\/R injury.<\/jats:p>","DOI":"10.1155\/2016\/7961940","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T17:01:59Z","timestamp":1468947719000},"page":"1-11","source":"Crossref","is-referenced-by-count":18,"title":["Caffeoylquinic Acid Derivatives Extract of<i>Erigeron multiradiatus<\/i>Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-8740","authenticated-orcid":true,"given":"Zhifeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Qinghai-Tibetan Plateau, Southwest University for Nationalities, Chengdu, Sichuan 610041, 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