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The probable protective effects of n\u20103 PUFA against carbon\u2010tetrachloride\u2010 (CCl<jats:sub>4<\/jats:sub>\u2010) induced acute liver injury were evaluated in a <jats:italic>fat-1<\/jats:italic> transgenic mouse that synthesizes endogenous n\u20103 from n\u20106 PUFA. <jats:italic>Fat-1<\/jats:italic> mice and their WT littermates were fed a modified AIN93 diet containing 10% corn oil and were injected intraperitoneally with a single dose of CCl<jats:sub>4<\/jats:sub> or vehicle. CCl<jats:sub>4<\/jats:sub> challenge caused severe liver injury in WT mice, as indicated by serum parameters and histopathological changes, which were remarkably ameliorated in <jats:italic>fat-1<\/jats:italic> mice. Endogenous n\u20103 PUFA decreased the elevation of oxidative stress induced by CCl<jats:sub>4<\/jats:sub> challenge, which might be attributed to the activation of Nrf2\/keap1 pathway. Additionally, endogenous n\u20103 PUFA reduces hepatocyte apoptosis via suppressing MAPK pathway. These findings indicate that n\u20103 PUFA has potent protective effects against acute liver injury induced by CCl<jats:sub>4<\/jats:sub> in mice, suggesting that n\u20103 PUFA can be used for the prevention and treatment of liver injury.<\/jats:p>","DOI":"10.1155\/2016\/7962948","type":"journal-article","created":{"date-parts":[[2016,11,6]],"date-time":"2016-11-06T21:01:52Z","timestamp":1478466112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endogenous n\u20103 Fatty Acids Alleviate Carbon\u2010Tetrachloride\u2010Induced Acute Liver Injury in <i>Fat-1<\/i> Transgenic 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