{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:46:46Z","timestamp":1762004806337},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently in immunocompetent patients. The mortality of the disease is very high, regardless of an early diagnosis and aggressive treatment. Here, we report a case of a 56\u2009yr old previously healthy woman who was found unconscious at home and admitted to the emergency room with mild respiratory insufficiency. In the first 24 hours she developed an acute respiratory failure with new radiographic infiltrates requiring Intensive Care Unit admission. A severe obstructive pattern with impossibility of ventilation because of bilateral atelectasis was observed, requiring emergent venovenous extracorporeal membrane oxygenator device insertion. Bronchoscopy revealed occlusion of main bronchi, demonstrating by biopsy an invasive infection by<jats:italic>Aspergillus fumigatus<\/jats:italic>and<jats:italic>A. flavus<\/jats:italic>. Despite an aggressive treatment and vital support the patient had a fatal outcome. The forensic study confirms the diagnosis of IPA but also revealed the presence of disseminated aspergillosis.<\/jats:p>","DOI":"10.1155\/2016\/7984032","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T17:01:33Z","timestamp":1462467693000},"page":"1-5","source":"Crossref","is-referenced-by-count":12,"title":["Invasive Pulmonary Aspergillosis with Disseminated Infection in Immunocompetent Patient"],"prefix":"10.1155","volume":"2016","author":[{"given":"Gabriel","family":"Moreno-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S\/N, Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Ricart de Mesones","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S\/N, Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Tazi-Mezalek","sequence":"additional","affiliation":[{"name":"Bronchoscopy Department, Bellvitge University Hospital, Feixa Llarga, S\/N, Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Marron-Moya","sequence":"additional","affiliation":[{"name":"Forensic Laboratory, Institute of Legal Medicine of Catalunya, Gran Via de les Corts Catalanes 111, 08075 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Rosell","sequence":"additional","affiliation":[{"name":"Bronchoscopy Department, Bellvitge University Hospital, Feixa Llarga, S\/N, Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Ma\u00f1ez","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Bellvitge University Hospital, Feixa Llarga, S\/N, Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm035"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200401-093OC"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0456"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0722-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200906-050al"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1086\/518852"},{"issue":"4","key":"4","first-page":"222","volume":"60","year":"2011","journal-title":"Pneumologia"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/385190"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.09.2011.4866"},{"issue":"1","key":"10","first-page":"73","volume":"39","year":"2006","journal-title":"Journal of Microbiology, Immunology and Infection"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-709"},{"issue":"12","key":"12","first-page":"5075","volume":"7","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02283.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s1130-1406(08)70041-x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2007.19.3.339"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.248.12.1495"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2016\/7984032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2016\/7984032.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2016\/7984032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T23:04:46Z","timestamp":1471561486000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crj\/2016\/7984032\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":18,"alternative-id":["7984032","7984032"],"URL":"https:\/\/doi.org\/10.1155\/2016\/7984032","relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"type":"print","value":"1198-2241"},{"type":"electronic","value":"1916-7245"}],"subject":[],"published":{"date-parts":[[2016]]}}}