{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:30Z","timestamp":1740171810446,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000445","K12HL109019"],"award-info":[{"award-number":["UL1TR000445","K12HL109019"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1TR000445","K12HL109019"],"award-info":[{"award-number":["UL1TR000445","K12HL109019"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The purpose of this study was to determine the diagnostic test characteristics of serum neuregulin-1<jats:italic>\u03b2<\/jats:italic>(NRG-1<jats:italic>\u03b2<\/jats:italic>) for the detection of acute coronary syndrome (ACS). We recruited emergency department patients presenting with signs and symptoms prompting an evaluation for ACS. Serum troponin and neuregulin-1<jats:italic>\u03b2<\/jats:italic>levels were compared between those who had a final discharge diagnosis of myocardial infarction (STEMI and NSTEMI) and those who did not, as well as those who more broadly had a final discharge diagnosis of ACS (STEMI, NSTEMI, and unstable angina). Of 319 study participants, 11% had evidence of myocardial infarction, and 19.7% had a final diagnosis of ACS. Patients with MI had median neuregulin levels of 0.16\u2009ng\/mL (IQR [0.16\u201324.54]). Compared to the median of those without MI, 1.46\u2009ng\/mL (IQR [0.16\u201315.02]), there was no significant difference in the distribution of results (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.63<\/mml:mn><\/mml:math>). Median neuregulin levels for patients with ACS were 0.65\u2009ng\/mL (IQR [0.16\u201324.54]). There was no statistical significance compared to those without ACS who had a median of 1.40\u2009ng\/mL (IQR [0.16\u201314.19]) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.95<\/mml:mn><\/mml:math>). Neuregulin did not perform successfully as a biomarker for acute MI or ACS in the emergency department.<\/jats:p>","DOI":"10.1155\/2016\/8025271","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T17:02:31Z","timestamp":1458838951000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Utility of Neuregulin for Acute Coronary Syndrome"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-0764","authenticated-orcid":true,"given":"Maame Yaa A. B.","family":"Yiadom","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas B.","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahred","family":"Carlise","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tortora","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Vanderbilt University School of Medicine, 703 Oxford House, 1313 21st Avenue S., Nashville, TN 37232, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Storrow","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, 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