{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:39Z","timestamp":1791412059845,"version":"4.3.3"},"reference-count":116,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies. \n<jats:italic>Data Sources<\/jats:italic>. MEDLINE was searched using keywords related to \u201cendothelial progenitor cells\u201d and \u201cendothelium\u201d and, for the different categories, respectively, \u201csmoking\u201d; \u201cblood pressure\u201d; \u201cdiabetes mellitus\u201d or \u201cinsulin resistance\u201d; \u201cdyslipidemia\u201d; \u201caging\u201d or \u201celderly\u201d; \u201cangina pectoris\u201d or \u201cmyocardial infarction\u201d; \u201cstroke\u201d or \u201ccerebrovascular disease\u201d; \u201chomocysteine\u201d; \u201cC\u2010reactive protein\u201d; \u201cvitamin D\u201d. <jats:italic>Study Selection<\/jats:italic>. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 quantitative studies were included. <jats:italic>Data Syntheses<\/jats:italic>. EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative\/reparative potential, and also as prognostic markers. <jats:italic>Conclusions<\/jats:italic>. EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings. Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. This trial is registered with registration number: Prospero <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.asp?ID=CRD42015023717\">CRD42015023717<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2016\/8043792","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T21:17:18Z","timestamp":1451423838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-6602","authenticated-orcid":false,"given":"Caterina Oriana","family":"Aragona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-5467","authenticated-orcid":false,"given":"Egidio","family":"Imbalzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-7472","authenticated-orcid":false,"given":"Federica","family":"Mamone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cairo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-0314","authenticated-orcid":false,"given":"Alberto","family":"Lo Gullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D\u2019Ascola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-2542","authenticated-orcid":false,"given":"Maria Adriana","family":"Sardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Scuruchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-5676","authenticated-orcid":false,"given":"Antonino","family":"Saitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mandraffino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000036417.43987.d8"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1051"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.03.046"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.952.003k27_952_958"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03077.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.070046397"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.093953"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa022287"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-043471"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1396"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24423"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.109.134213"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00598.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1002-8"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.07.009"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.155960"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.216879"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.040"},{"key":"e_1_2_7_20_2","first-page":"922","article-title":"Toll-like receptor 3 and interleukin 1beta expression in CD34+ cells from patients with rheumatoid arthritis: association with inflammation and vascular involvement","volume":"32","author":"Lo Gullo A.","year":"2014","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.745"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1661"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.243386"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.02.003"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa043814"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000066691.52789.be"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.126078"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-099481"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.06.045"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090314"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000135655.52088.c5"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.10.009"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4103"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000146815.54702.75"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp031"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.09.023"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq455"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt382"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)11911-8"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp141"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1002304"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.03.100"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.31"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0b013e3280109271"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.7"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243386"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl198"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.1.195"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.fp0060256"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0939-6"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3087-6"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22109"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0180-0"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6520"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.563213"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X10367537"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.03.039"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs20080263"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm196603312741302"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199806043382302"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199901143400207"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs20030389"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2004.04022.x"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90874-9"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.05.003"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000164260.82417.3f"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00601.2003"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1395.038"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01363.x"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1126\/sageke.2003.45.re8"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.09.016"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.074"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.012"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.179820"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.03.007"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.006866"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-011-9305-6"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000124476.32871.e3"},{"key":"e_1_2_7_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.03.026"},{"key":"e_1_2_7_83_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc2301.092122"},{"key":"e_1_2_7_84_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1831"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000149944.15406.16"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133311.25587.DE"},{"key":"e_1_2_7_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.489401"},{"key":"e_1_2_7_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.484386"},{"key":"e_1_2_7_89_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa021993"},{"key":"e_1_2_7_90_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2481"},{"key":"e_1_2_7_91_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000089190.95415.9f"},{"key":"e_1_2_7_92_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112334"},{"key":"e_1_2_7_93_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000127577.63323.24"},{"key":"e_1_2_7_94_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530190040032"},{"key":"e_1_2_7_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.10.005"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0856"},{"key":"e_1_2_7_97_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.706127"},{"key":"e_1_2_7_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.069"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.04.024"},{"key":"e_1_2_7_100_2","first-page":"81","article-title":"Vitamin D concentrations, endothelial progenitor cells, and cardiovascular risk factors","volume":"52","author":"Mikirova N. A.","year":"2010","journal-title":"Panminerva Medica"},{"key":"e_1_2_7_101_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000043246.74879.cd"},{"key":"e_1_2_7_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0327-y"},{"key":"e_1_2_7_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034046.87607.1C"},{"key":"e_1_2_7_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)67861-0"},{"key":"e_1_2_7_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp113"},{"key":"e_1_2_7_106_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp374"},{"key":"e_1_2_7_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jep191"},{"key":"e_1_2_7_108_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV3I3A64"},{"key":"e_1_2_7_109_2","doi-asserted-by":"publisher","DOI":"10.4244\/eijv3i3a64"},{"key":"e_1_2_7_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.048"},{"key":"e_1_2_7_111_2","doi-asserted-by":"publisher","DOI":"10.1097\/mca.0b013e328351550f"},{"key":"e_1_2_7_112_2","doi-asserted-by":"publisher","DOI":"10.4244\/eijv6i7a141"},{"key":"e_1_2_7_113_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/931420"},{"key":"e_1_2_7_114_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.23374"},{"key":"e_1_2_7_115_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000137877.89448.78"},{"key":"e_1_2_7_116_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00330.2003"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/8043792.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2016\/8043792.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/8043792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:22:22Z","timestamp":1722910942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/8043792"}},"subtitle":[],"editor":[{"given":"Dominik","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,12,29]]},"references-count":116,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/8043792"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8043792","archive":["Portico"],"relation":{},"ISSN":["1687-966X","1687-9678"],"issn-type":[{"value":"1687-966X","type":"print"},{"value":"1687-9678","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,29]]},"assertion":[{"value":"2015-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8043792"}}