{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:15:31Z","timestamp":1787454931743,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. There are limited epidemiological studies evaluating the effect of age at onset on disease features in vitiligo.<jats:italic>Objectives<\/jats:italic>. To identify factors associated with adult onset vitiligo in comparison with childhood onset vitiligo.<jats:italic>Patients and Methods<\/jats:italic>. We retrospectively collected medical records of 191 patients. Such records included clinical examination, personal and familial medical history, laboratory evaluations, concomitant vitiligo treatment and drug assumption.<jats:italic>Results<\/jats:italic>. 123 patients with a disease onset after the age of 40 (adult onset vitiligo) were compared with 68 patients who developed vitiligo before the age of 12 (childhood onset vitiligo). Multivariate analysis revealed that personal history of thyroid diseases (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">04<\/mml:mn><\/mml:math>; OR 0.4), stress at onset (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>; OR = 0.34), personal history of autoimmune thyroid disease (ATD) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.003<\/mml:mn><\/mml:math>; OR = 0.23), and thyroid nodules (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>; OR 0.90) were independently associated with adult onset vitiligo, whereas family history of dermatological diseases (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.003<\/mml:mn><\/mml:math>; OR = 2.87) and Koebner phenomenon (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>; OR = 4.73) with childhood onset vitiligo. Moreover, in the adult onset group, concomitant thyroid disease preceded vitiligo in a statistically significant number of patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.014<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Childhood onset and adult onset vitiligo have different clinical features. In particular, ATD and thyroid nodules were significantly associated with adult onset vitiligo, suggesting that a thyroid screening should be recommended in this group of patients.<\/jats:p>","DOI":"10.1155\/2016\/8065765","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T17:11:13Z","timestamp":1474564273000},"page":"1-5","source":"Crossref","is-referenced-by-count":28,"title":["Adult Onset Vitiligo: Multivariate Analysis Suggests the Need for a Thyroid Screening"],"prefix":"10.1155","volume":"2016","author":[{"given":"L.","family":"Lazzeri","sequence":"first","affiliation":[{"name":"Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-7957","authenticated-orcid":true,"given":"R.","family":"Colucci","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cammi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dragoni","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-7690","authenticated-orcid":true,"given":"S.","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb02067.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00192.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2003.20304.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.113.1.47"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01948.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2013.12075"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04171.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04614.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14640"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11002.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.010"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01749.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.027"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02106.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02764.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04665.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11198.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4412"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.019"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.11.021"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.04.013"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2012.1884"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.010"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8065765.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8065765.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/8065765.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T17:11:13Z","timestamp":1474564273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2016\/8065765\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":24,"alternative-id":["8065765","8065765"],"URL":"https:\/\/doi.org\/10.1155\/2016\/8065765","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}