{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:59:59Z","timestamp":1780073999839,"version":"3.54.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171098"],"award-info":[{"award-number":["31171098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. We object to elucidate that protective effect of H<jats:sub>2<\/jats:sub>S on endothelium is mediated by downregulating BMP4 (bone morphogenetic protein 4)\/cyclooxygenase\u2010 (COX\u2010) 2 pathway in rats with hypertension. <jats:italic>Methods and Results<\/jats:italic>. The hypertensive rat model induced by two\u2010kidney one\u2010clip (2K1C) model was used. Exogenous NaHS administration (56\u2009<jats:italic>\u03bc<\/jats:italic>mol\/kg\/day, intraperitoneally once a day) reduced mean arterial pressure (MAP) of 2K1C rats from 199.9 \u00b1 3.312\u2009mmHg to 159.4 \u00b1 5.434\u2009mmHg, while NaHS did not affect the blood pressure in the Sham rats and ameliorated endothelium\u2010dependent contractions (EDCs) of renal artery in 2K1C rats. 2K1C reduced CSE level twofold, decreased plasma levels of H<jats:sub>2<\/jats:sub>S about 6\u2010fold, increased BMP4, Nox2, and Nox4 levels 2\u2010fold and increased markers of oxidative stress MDA and nitrotyrosine 1.5\u2010fold, upregulated the expression of phosphorylation\u2010p38 MAPK 2\u2010fold, and increased protein levels of COX\u20102 1.5\u2010fold, which were abolished by NaHS treatment. <jats:italic>Conclusions<\/jats:italic>. Our results demonstrate that H<jats:sub>2<\/jats:sub>S prevents activation of BMP4\/COX\u20102 pathway in hypertension, which may be involved in the ameliorative effect of H<jats:sub>2<\/jats:sub>S on endothelial impairment. These results throw light on endothelial protective effect of H<jats:sub>2<\/jats:sub>S and provide new target for prevention and therapy of hypertension.<\/jats:p>","DOI":"10.1155\/2016\/8128957","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T21:02:19Z","timestamp":1471986139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4\/COX\u20102 Pathway in Rats with Hypertension"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-0007","authenticated-orcid":false,"given":"Lin","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-9453","authenticated-orcid":false,"given":"Jing-Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-9700","authenticated-orcid":false,"given":"Sheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-0843","authenticated-orcid":false,"given":"Hong-Mei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-2929","authenticated-orcid":false,"given":"Qi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2206-8308","authenticated-orcid":false,"given":"Xu","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-056X","authenticated-orcid":false,"given":"Yu-Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,23]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2253"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03386.2002"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp111"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2011.22.038"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-013-0920-x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.326"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053147"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105121108"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00104"},{"key":"e_1_2_8_12_2","first-page":"541","article-title":"Hypotensive effects of hydrogen sulfide via attenuating vascular inflammation in spontaneously hypertensive rats","volume":"36","author":"Jin H.-F.","year":"2008","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/08977190412331279890"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.041673"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.09.001"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90068-T"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-009-0099-x"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0368-x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.100229"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.236596"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.611822"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12350"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00180.2008"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.110.222794"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932848"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.179770"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707190"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.01.025"},{"key":"e_1_2_8_29_2","first-page":"170","article-title":"Unraveling the mystery of goldblatt hypertension","volume":"13","author":"Navar L. 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